Figure 5
From: Cigarette smoke increases cardiomyocyte ceramide accumulation and inhibits mitochondrial respiration
Western diet exerts a minimal effect on heart ceramides in smoke-exposed mice. Mice were exposed to room air (Con) or cigarette smoke (CS) for 8 wk while receiving PBS (vehicle) or myriocin injections every other day. Mice also received either a standard diet (SD) or Western diet (WD). A: Ceramides were measured from left ventricle following treatment period (n = 4). B: Mitochondrial respiration was determined from permeabilized left ventricle myocardium (n = 8). *P <0.05 for treatment vs. Vehicle SD. #P <0.05 for WD + CS myriocin vs. WD + CS vehicle.