Mapping of a blood pressure QTL on chromosome 17 in American Indians of the strong heart family study

Franceschini, Nora; Tao, Ran; Liu, Lan; Rutherford, Sue; Haack, Karin; Almasy, Laura; Göring, Harald HH; Laston, Sandra; Lee, Elisa T; Best, Lyle G; Fabsitz, Richard; Cole, Shelley A; North, Kari E

doi:10.1186/1471-2261-14-158

BMC Cardiovascular Disorders

Table 2 Comparison of effect size and p-values from analyses using individuals selected from families showing linkage for SBP (Panel 1) and analyses using the entire SHFS (Panel 2)

From: Mapping of a blood pressure QTL on chromosome 17 in American Indians of the strong heart family study

					Panel 1				Panel 2
Gene	SNV	Effect allele	Other allele	Frequency effect allele	Beta	SE	P-value	P-value heterogeneity	Beta	SE	P-value
TBC1D16	rs2362384	G	A	0.05	0.0469	0.0149	0.002	0.6897	0.0065	0.0076	0.39
AZI1	rs12939525	G	A	0.17	−0.0231	0.0084	0.006	0.3663	−0.0063	0.0040	0.12
AZI1	rs9896850	G	A	0.82	0.0227	0.0083	0.006	0.336	0.0065	0.0040	0.11
TBC1D16	rs1115834	G	A	0.86	−0.0223	0.0085	0.009	0.3448	0.0005	0.0042	0.91
HRNBP3	rs11656673	G	A	0.86	−0.0239	0.0093	0.01	0.9068	−0.0082	0.0052	0.12
AZI1	rs9913021	G	A	0.17	−0.0204	0.0083	0.01	0.5889	−0.0062	0.0040	0.12
AZI1	rs9789009	G	A	0.11	−0.0248	0.0103	0.02	0.2532	−0.0134	0.0051	0.009
BRAP	rs11065987	G	A	0.18	−0.0228	0.0095	0.02	0.266	−0.0056	0.0046	0.22
UTS2R	rs11658052	G	A	0.91	0.0232	0.0099	0.02	0.3044	0.0037	0.0044	0.39
HRNBP3	rs11651204	G	A	0.40	−0.0133	0.0057	0.02	0.00073	−0.004	0.003	0.18
LOC344371	rs6711736	G	A	0.77	−0.0151	0.0067	0.02	0.5462	−0.0012	0.0033	0.72
LOC344371	rs9308945	G	A	0.23	0.0151	0.0067	0.02	0.5462	0.001	0.0033	0.77
HRNBP3	rs1563448	G	A	0.89	−0.0244	0.0113	0.03	0.4723	−0.0106	0.0063	0.09
ATP2B1	rs2681472	G	A	0.08	−0.0254	0.0119	0.03	0.2504	−0.0174	0.0062	0.005
ATP2B1	rs17249754	G	A	0.92	0.0253	0.0118	0.03	0.2626	0.0177	0.0062	0.004
ATP2B1	rs2681492	G	A	0.08	−0.0252	0.0118	0.03	0.263	−0.0172	0.0062	0.005
HRNBP3	rs4789976	G	A	0.84	0.0177	0.0083	0.03	0.9945	0.0071	0.0039	0.07
LOC344371	rs6729869	T	A	0.76	−0.0143	0.0067	0.03	0.5041	−0.0007	0.0033	0.84
HRNBP3	rs12937212	G	A	0.84	0.0176	0.0083	0.03	0.995	0.0068	0.0039	0.08
HRNBP3	rs12940295	C	A	0.16	−0.0182	0.0088	0.04	0.8109	−0.01	0.0043	0.02
SLC39A11	rs2567494	C	A	0.59	0.0121	0.0059	0.04	0.9385	−0.0012	0.003	0.69
HRNBP3	rs866414	C	A	0.81	0.0149	0.0075	0.05	0.3581	0.0014	0.0037	0.71
SLC39A11	rs7210946	G	A	0.53	−0.0116	0.0059	0.05	0.9928	0.0023	0.003	0.44
HRNBP3	rs10445220	C	A	0.73	0.013	0.0066	0.05	0.1092	0.0043	0.0034	0.20

SNV, single nucleotide polymorphism; het, heterogeneity; SE, standard error.

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ISSN: 1471-2261

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