Table 3 Genes with significantly higher expression (>2 times) in the ivabradine group than in the control group

MMP -2(matrix metallopeptidase- 2)

ECM

0.027

0.067

0.40

0.031

MIP-3 β(macrophage inflammation protein-3 β, CCL 19)

Lymphoid T cells

0.319

0.144

2.22

0.014

6Ckine(chemokine with 6 cysteines,CCL21)

Lymphoid organs

0.421

0.177

2.37

0.024

ACE/CD143(angiogensin I Converting Enzyme/CD 143)

RAAS

0.433

0.189

2.29

0.006

ALK-1(activin receptor-like kinase)

TGF- β

0.327

0.123

2.66

0.047

CT-1(cardiotrophin-1)

apoptosis

0.292

0.086

3.39

0.016

CD27(CD-27)

apoptosis

0.245

0.089

2.75

0.021

CD27 Ligand(CD70)

TNF

0.212

0.067

3.16

0.020

Endoglin(endoglin)

TGF- β

0.333

0.159

2.09

0.005

Epigen(epigen)

EGF-like

0.173

0.0845

2.05

0.039

IL-17E(interlukin-17E)

T cells

0.327

0.161

2.03

0.001

IL-17 F(interlukin-17 F)

T cells

0.385

0.163

2.36

0.001

IL-1ra/IL-1 F3(interlukin-1ra/-1 F3)

T cells

0.266

0.121

2.19

0.003

IL-2 Rα(interlukin-2 Rα)

T cells

0.298

0.143

2.08

0.001