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Table 3 Genes with significantly higher expression (>2 times) in the ivabradine group than in the control group

From: I(f) current channel inhibitor (ivabradine) deserves cardioprotective effect via down-regulating the expression of matrix metalloproteinase (MMP)-2 and attenuating apoptosis in diabetic mice

Gene name Function IVBD (mean) Control (mean) FC P
MMP -2(matrix metallopeptidase- 2) ECM 0.027 0.067 0.40 0.031
MIP-3 β(macrophage inflammation protein-3 β, CCL 19) Lymphoid T cells 0.319 0.144 2.22 0.014
6Ckine(chemokine with 6 cysteines,CCL21) Lymphoid organs 0.421 0.177 2.37 0.024
ACE/CD143(angiogensin I Converting Enzyme/CD 143) RAAS 0.433 0.189 2.29 0.006
ALK-1(activin receptor-like kinase) TGF- β 0.327 0.123 2.66 0.047
CT-1(cardiotrophin-1) apoptosis 0.292 0.086 3.39 0.016
CD27(CD-27) apoptosis 0.245 0.089 2.75 0.021
CD27 Ligand(CD70) TNF 0.212 0.067 3.16 0.020
Endoglin(endoglin) TGF- β 0.333 0.159 2.09 0.005
Epigen(epigen) EGF-like 0.173 0.0845 2.05 0.039
IL-17E(interlukin-17E) T cells 0.327 0.161 2.03 0.001
IL-17 F(interlukin-17 F) T cells 0.385 0.163 2.36 0.001
IL-1ra/IL-1 F3(interlukin-1ra/-1 F3) T cells 0.266 0.121 2.19 0.003
IL-2 Rα(interlukin-2 Rα) T cells 0.298 0.143 2.08 0.001
  1. Fold changes are relative to normal samples.
  2. FC, fold change; ECM, extracellular matrix; RAAS, renin angiotensin aldosterone system; TGF, tissue growth factor; TNF, tumor necrosis factor; EGF, epidermal growth factor.