Table 1 Baseline Characteristics
Variable | TOTAL N = 425 | Appropriate N = 272 | Inappropriate N = 57 | Uncertain N = 96 | P-value | Medical N = 130 | Revascularization N = 295 | P-value |
|---|---|---|---|---|---|---|---|---|
Age Mean ± SD | 65.34 ± 10.86 | 66.04 ± 11.04 | 64.11 ± 10.90 | 64.09 ± 10.23 | 0.852 | 65.52 ± 11.69 | 65.26 ± 10.49 | 0.823 |
Male | 79.1% | 80.1% | 78.9% | 76.0% | 0.123 | 84.6% | 76.6% | 0.155 |
Diabetes | 35.1% | 38.2% | 21.1% | 34.4% | 0.047 | 36.9% | 34.2% | 0.593 |
Hypertension | 74.8% | 75.0% | 73.7% | 75.0% | 0.475 | 80.8% | 72.2% | 0.152 |
Hyperlipidemia | 89.9% | 89.7% | 89.5% | 90.6% | 0.443 | 90.8% | 89.5% | 0.764 |
Smoking | 60.0% | 62.1% | 52.6% | 58.3% | 0.409 | 53.1% | 3.1% | 0.061 |
Symptom Severity | ||||||||
CCS 0 | 19.8% | 12.1% | 40.4% | 29..2% | <0.001 | 23.1% | 18.3% | 0.029 |
CCS 1-2 | 48.9% | 44.1% | 59.6% | 56.3% | 54.6% | 46.4% | ||
CCS 3-4 | 31.3% | 43.8% | 0% | 14.6% | 22.3% | 35.3% | ||
LV ejection Fraction | ||||||||
> = 60% | 56.0% | 54.4% | 68.4% | 53.1% | 0.371 | 48.5% | 59.3% | 0.039 |
40-59% | 21.9% | 22.4% | 14.0% | 25.0% | 30.0% | 18.3% | ||
20-39% | 9.4% | 11.0% | 8.8% | 5.2% | 10.0% | 9.2% | ||
<=20% | 0.7% | 0.7% | 0.0% | 1.0% | 1.5% | 0.3% | ||
NA | 12.0% | 11.4% | 8.8% | 15.6% | 10.0% | 12.9% | ||
Coronary Anatomy | ||||||||
1 -or 2 vessel CAD without involvement of proximal LAD | 55.1% | 40.8% | 100.0% | 68.8% | <.001 | 63.8% | 51.2% | 0.016 |
Chronic total occlusion of 1 major epicaridial coronary artery without other coronary stenoses | 0.5% | 0.7% | 0.0% | 0.0% | 0.568 | 0.0% | 0.7% | 0.347 |
1- vessel CAD involving the proximal LAD | 8.0% | 8.8% | 0.0% | 10.4% | 0.051 | 4.6% | 9.5% | 0.088 |
2-vessel CAD involving the proximal LAD | 4.7% | 3.7% | 0.0% | 10.4% | 0.005 | 4.6% | 4.7% | 0.953 |
3-vessel CAD (no left main) | 18.8% | 25.7% | 0.0% | 10.4% | <.001 | 17.7% | 19.3% | 0.692 |
left main stenosis | 13.4% | 21.0% | 0.0% | 0.0% | <.001 | 9.2% | 15.3% | 0.093 |
Previous CABG | 16.7% | 19.9% | 1.8% | 16.7% | 0.005 | 28.5% | 11.5% | <.001 |
Previous CHF | 6.4% | 6.6% | 3.5% | 7.3% | 0.74 | 12.3% | 3.7% | 0.003 |
Previous PCI | 29.9% | 29.4% | 29.8% | 31.3% | 0.159 | 34.6% | 27.8% | 0.11 |
Prior MI | 34.8% | 33.8% | 28.1% | 41.7% | 0.236 | 43.1% | 31.2% | 0.043 |
PVD | 12.5% | 11.8% | 12.3% | 14.6% | 0.806 | 13.8% | 11.9% | 0.553 |
Creatinine Mean ± SD | 95.92 ± 68.21 | 90.89 ± 23.96 | 94.46 ± 44.47 | 111.04 ± 132.88 | 0.221 | 106.38 ± 106.79 | 91.31 ± 40.45 | 0.971 |
Dialysis | 1.4% | 0.7% | 1.8% | 3.1% | 0.227 | 2.3% | 1.0% | 0.299 |
Stroke | 9.6% | 9.9% | 14.0% | 6.3% | 0.351 | 8.5% | 10.2% | 0.831 |
Dementia | 0.7% | 0.7% | 0.0% | 1.0% | 0.341 | 0.8% | 0.7% | 0.102 |
Cancer | 10.4% | 11.8% | 8.8% | 7.3% | 0.703 | 7.7% | 11.5% | 0.01 |
COPD | 7.5% | 8.8% | 7.0% | 4.2% | 0.327 | (4.6% | 8.8% | 0.131 |
Medications | ||||||||
% on Maximal Anti-anginal Therapy | 26.1% | 32.0% | 7.0% | 20.8% | <.001 | 20.8% | 28.5% | 0.096 |
ACE inhibitor/ARB | 67.5% | 66.9% | 68.4% | 68.8% | 0.936 | 72.3% | 65.4% | 0.163 |
Statin | 82.1% | 83.1% | 82.5% | 79.2% | 0.688 | 81.5% | 82.4% | 0.836 |
Β-Blocker | 66.4% | 68.8% | 56.1% | 65.6% | 0.184 | 71.5% | 64.1% | 0.133 |
Treatment Strategy | ||||||||
CABG | 18.4% | 21.7% | 14.0% | 11.5% | 0.002 | 0.0% | 26.4% | <.001 |
Medical | 30.6% | 24.6% | 47.4% | 37.5% | 130 100.0% | 0.0% | ||
PCI | 51.1% | 53.7% | 38.6% | 51.0% | 0.0% | 73.6% | ||
Outcomes | ||||||||
1- year Mortality | 2.6% | 2.6% | 0.0% | 4.2% | 0.292 | 5.4% | 1.4% | 0.016 |
1-year Readmission for MI | 9.9% | 10.3% | 7.0% | 10.4% | 0.738 | 5.4% | 11.9% | 0.039 |
1-year repeat PCI/CABG | 10.4% | 12.5% | 3.5% | 8.3% | 0.098 | 5.4% | 12.5% | 0.026 |