Chronic high-fat diet-induced obesity decreased survival and increased hypertrophy of rats with experimental eccentric hypertrophy from chronic aortic regurgitation

Table 1 Biometric and echocardiographic parameters

	Sham Ctrl	Sham HF	AR Ctrl	AR HF
Tibia, mm	60.3 ± 0.64	61.4 ± 0.31	61.0 ± 0.43	61.0 ± 0.56
LV, mg	1163 ± 34.0	1225 ± 34.2	1823 ± 77.0a	2046 ± 69.9a, c
EDD, mm	8.4 ± 0.14	8.5 ± 0.17	11.4 ± 0.18a	11.6 ± 0.18a
ESD, mm	3.8 ± 0.22	3.8 ± 0.20	6.7 ± 0.17a	6.6 ± 0.22a
EF,%	78.6 ± 1.81	80.1 ± 1.52	64.8 ± 1.05a	67.9 ± 1.63a
RWT	0.30 ± 0.005	0.29 ± 0.005	0.23 ± 0.005a	0.21 ± 0.005a
kCal/day	126 ± 4.0	130 ± 4.0	126 ± 2.3	134 ± 4.1
TG, mmol/l	1.1 ± 0.12	1.1 ± 0.12	1.4 ± 0.14	1.0 ± 0.11
Chol., mmol/l	3.1 ± 0.46	2.9 ± 0.12	2.6 ± 0.13	3.1 ± 0.17
Gluc., mmol/l	17.4 ± 1.53	17.3 ± 1.72	15.9 ± 1.19	15.0 ± 1.05
Insulin, μg/l	1.4 ± 0.25	1.1 ± 0.19	1.6 ± 0.21a	2.4 ± 0.70a
Leptin, mg/l	1.1 ± 0.17	2.0 ± 0.22b	0.7 ± 0.13	2.1 ± 0.22b
Adiponectin, mg/l	10.4 ± 0.76	10.4 ± 0.69	7.7 ± 0.34	10.4 ± 0.76c

Echo measurements obtained under 1.5% isoflurane anesthesia. LV left ventricle, EDD end-diastolic diameter, ESD end-systolic diameter, EF ejection fraction and RWT relative wall thickness. Animal daily food intake (kCal/day) and plasma levels of glucose, triglycerides, insulin, leptin and adiponectin plasma levels were estimated in animals sacrificed at 60 days post-AR. a: p < 0.001 versus sham groups, b: p < 0.01 vs. control diet groups and c: p < 0.01 vs. corresponding AR group by Bonferroni post-test. HF: high-fat diet.

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