Table 1 Demographics and CPET parameters of study population (n = 66)
TOF (n = 36) | Control (n = 30) | P value | Adjusted P value* | |
|---|---|---|---|---|
Demographics | ||||
Age | 25.2 (19.5, 31.7) | 27.8 (21.0, 32.8) | 0.20 | |
Male | 29 (80.6) | 24 (80.0) | 1.00 | |
BMI (kg/m2) | 22.8 (21.0, 26.3) | 23.2 (19.6, 25.6) | 0.39 | |
Asymptomatic/NYHA I | 30 (83.3) | 30 (100.0) | 0.03 | |
CPET parameters | ||||
Max HR (beats/min) | 172.5 (159, 178) | 176.5 (168, 181) | 0.257 | 0.429 |
Heart rate reserve (beats/min) | 26.5 (8, 39) | 15.5 (7, 20) | 0.117 | 0.183 |
Max SBP (mmHg) | 177 (150, 184) | 192 (168, 210) | 0.007 | 0.010 |
Max DBP (mmHg) | 86 (78, 93) | 82 (76, 97) | 0.575 | 0.964 |
Max breathing reserve (L/min) | 38 (21, 72.1) | 47.8 (34.5, 61.3) | 0.540 | 0.602 |
Mets | 8.3 (7.1, 9.4) | 9.9 (8.6,11.7) | <0.001 | <0.001 |
% predicted Mets (%) | 85.0 (74.8, 93.9) | 102.7 (91.1, 114.5) | <0.001 | <0.001 |
Peak oxygen consumption (ml/kg/min) | 29.2 (25.5, 33.0) | 34.5 (30.0, 41.0) | <0.001 | <0.001 |
% predicted peak oxygen consumption (%) | 83.0 (72.0, 93.5) | 102.7 (91.1, 114.8) | <0.001 | <0.001 |
Anaerobic threshold (ml/min) | 1395 (1170, 1574) | 1501.5 (1255, 1700) | 0.231 | 0.211 |
Oxygen pulse pressure (ml/beat) | 11.0 (8.8, 13.2) | 13.7 (11.9, 16.2) | 0.003 | 0.002 |
VE/VCO2 slope | 26.0 (23.6, 27.3) | 25.6 (24.1, 27.2) | 1.00 | 0.576 |
Arrhythmias** | 7 (19.4) | 4 (13.3) | 0.742 | 0.492 |