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Table 1 Clinical characteristics of family 6652

From: Whole-exome sequencing in an extended family with myocardial infarction unmasks familial hypercholesterolemia

Family ID Pedigre ID Sex$ BMI (kg/m2) Age at first MI (years) Age at first CAD (years) LDL-C (mg/dL) Statin therapy Daily dose Hyper-cholesterol-emia1# Hyper-tension2# Diabetes3# Smoking4#
6652501 III.2 2 28.5   58 252 Atorvastatin 20 1 1 2 1
6652502 III.3 1 26.5   55 214 Atorvastatin 60 1 1 2 2
6652505 III.16 2 22.8    186    2 1 2 2
6652506 III.18 2 25.0   55 233 Atorvastatin 80 1 2 2 1
6652509 IV.6 2 26.4    184    2 2 2 1
6652511 III.6 1 25.9 44 67 189 Atorvastatin 10 1 1 2 1
6652512 III.20 1 30.5    136 Cerivastatin 0.3 1 1 2 2
6652513 IV.3 1 24.2    96    2 2 2 2
6652515 IV.5 2 23.4    171    2 2 2 1
6652516 IV.7 1 25.2   59 188 Atorvastatin 40 1 2 2 2
6652518 III.13 2 27.3    156    2 2 2 1
6652520 IV.9 1 22.5    142 Simvastatin 10 1   2 2
6652522 IV.13 1 29.4    166    2 2 2 1
6652523 IV.14 2 24.2    168    2 2 2 2
6652524 IV.15 2 23.5    130    2   2 2
6652525 IV.16 1 22.7    145    2 2 2 2
6652527 IV.20 2 23.4    143    2   2 1
6652531 IV.10 2 20.9    116 Atorvastatin 60 1 2 2 2
6652533 IV.12 2 21.3        2 2 2
6652534 III.19 1 23.1    115    2 1 2 2
6652535 IV.17 1 23.2    184    2 2 2 2
6652536 IV.18 1 22.8    274 Atorvastatin 20 1 2 2 2
  1. $:1 = male, 2 = female; #: 1 = yes, 2 = no; 1Blood pressure >140/90 mm Hg; 2LDL cholesterol > 190 mg/dL or statin therapy; 3History of diabetes mellitus; 4History of smoking. Index patient IV.7 in bold.