Table 5 Pathway analysis of the selected miRNAs

miR-1

hsa3040: Spliceosome

ISY1 DDX5 SFRS9 DHX15 HNRNPU TRA2B SFRS1 HNRNPA3 HNRNPK SFRS3

1.39E-03

hsa4320: Dorso-ventral axis formation

NOTCH2 EGFR NOTCH3 CPEB1 ETS1

3.86E-03

miR-26a-5p

hsa4115: p53 signaling pathway

CCNE2 CCNE1 PTEN CDK6 CCND2 IGF1 ATM

1.98E-03

hsa4010: MAPK signaling pathway

TGFBR2 MYC PPP3R1 CACNA1C PPP3CB MAP3K1 NLK PAK2

8.40E-03

miR-466

hsa4150: mTOR signaling pathway

PRKAA2 RPS6KA3 EIF4E ULK2 RICTOR

2.36E-03

hsa5200: Pathways in cancer

CCDC6 ARNT2 KIT CYCS COL4A1 GLI3 PTGS2 SMAD2 RUNX1T1 TGFB2 TCF7L2 DAPK1 MECOM

4.56E-03

miR-574-3p

hsa5200: Pathways in cancer

CUL2 EP300 ACVR1B RXRA

3.75E-03

hsa5016: Huntington's disease

EP300 CLTC

4.38E-03

hsa5211: Renal cell carcinoma

CUL2 EP300

9.33E-03

miR-3613-3p

hsa4520: Adherens junction

TCF7 EP300 CREBBP ACTN4 FGFR1 PTPRJ INSR TCF7L2 ACVR1C IGF1R CTNNB1 CTNND1 WASL LMO7 SMAD4

5.19E-06

hsa4310: Wnt signaling pathway

NFATC3 TCF7 NFAT5 EP300 CREBBP AXIN2 GSK3B PPP3CA VANGL2 TCF7L2 PPP2R5A WNT5A CCND2 PPP3R1 CCND1 CTNNB1 CSNK1A1 CSNK1E WNT4 SMAD4

9.31E-05

hsa4720: Long-term potentiation

EP300 CREBBP PPP1R12A PPP3CA PPP1CB PPP3R1 RPS6KA2 RAP1A GRIA1 KRAS

6.75E-04

hsa4330: Notch signaling pathway

JAG1 EP300 MAML3 CREBBP ADAM17 DLL1 NUMBL HDAC2

2.88E-03

hsa4910: Insulin signaling pathway

PRKCI PPP1R3B PPARGC1A ACACB GSK3B PRKAA1 INSR SOCS3 IRS1 EIF4E PPP1CB KRAS IRS2

6.80E-03

hsa4920: Adipocytokine signaling pathway

PPARGC1A ACACB PRKAA1 SOCS3 IRS1 STAT3 ACSL4 ACSL6 IRS2

8.20E-03