Table 1 Baseline characteristics
OAT-Biomarker (N = 70) | Remaining OAT (N = 2131) | ||||
|---|---|---|---|---|---|
n | % (mean ± sd) | N | % (mean ± sd) | p-value | |
Age (years) | 70 | (60.8 ± 8.8) | 2131 | (58.5 ± 11) | 0.097 |
Women | 17 | 24.3 | 467 | 21.9 | 0.637 |
Race White | 70 | 100 | 1693 | 79.4 | <.001 |
Clinical history | |||||
Angina | 15 | 21.4 | 480 | 22.5 | 0.829 |
Myocardial Infarction | 3 | 4.3 | 244 | 11.5 | 0.080 |
Percutaneous intervention | 4 | 5.7 | 101 | 4.7 | 0.574 |
Congestive heart failure | 1 | 1.4 | 51 | 2.4 | 1.000 |
Hypertension | 36 | 51.4 | 1035 | 48.6 | 0.638 |
Diabetes | 10 | 14.3 | 444 | 20.8 | 0.183 |
Insulin use | 6 | 8.6 | 118 | 5.5 | 0.279 |
Hypercholesterolemia | 31 | 44.3 | 1111 | 52.2 | 0.195 |
Stroke | 4 | 5.7 | 59 | 2.8 | 0.138 |
Cerebrovascular disease | 5 | 7.1 | 77 | 3.6 | 0.125 |
Peripheral vascular disease | 1 | 1.4 | 82 | 3.9 | 0.519 |
Current Smoker | 25 | 35.7 | 834 | 39.1 | 0.564 |
Family history CAD | 29 | 41.4 | 854 | 40.1 | 0.820 |
Days from MI to randomization - median {IQR} | 70 | 21{16–26} | 2131 | 8{5–16} | <.001 |
Index myocardial infarction | |||||
Received thrombolytics | 1 | 1.4 | 423 | 19.9 | <.001 |
STE / Q wave / R loss | 58 | 82.9 | 1849 | 86.8 | 0.344 |
Killip Class II-IV | 11 | 15.7 | 406 | 19.1 | 0.473 |
Ejection Fraction | 70 | (46.3 ± 9.7) | 2115 | (47.8 ± 11.1) | 0.275 |
Rales | 1 | 1.4 | 136 | 6.4 | 0.125 |
Clinical measures | |||||
Estimated GFR <60 ml/min/1.73 m2 | 8 | 11.4 | 305 | 14.6 | 0.453 |
Glucose > =126 mg/dl | 8 | 11.6 | 556 | 28.8 | 0.002 |
BMI (kg/m2) | 69 | (26.7 ± 3.6) | 2118 | (28.6 ± 5.1) | 0.003 |
Heart rate (bpm) | 70 | (69.3 ± 9.8) | 2128 | (71.9 ± 12) | 0.076 |
Systolic blood pressure (mmHg) | 70 | (120.4 ± 11.9) | 2129 | (120.8 ± 18.1) | 0.831 |
Angiography | |||||
Infarct-related artery (IRA) –LAD | 19 | 27.1 | 774 | 36.3 | . 0.267 |
Infarct-related artery (IRA) –Lcx | 11 | 15.7 | 324 | 15.2 | |
Infarct-related artery (IRA) –RCA | 40 | 57.1 | 1033 | 48.5 | |
Multivessel Disease | 21 | 30.4 | 358 | 16.9 | 0.004 |
Collaterals | 64 | 92.8 | 1858 | 88.3 | 0.256 |
Medications | |||||
Aspirin | 68 | 97.1 | 2037 | 95.6 | 0.767 |
Thienopyridine | 42 | 60 | 1287 | 60.4 | 0.947 |
Warfarin | 3 | 4.3 | 212 | 9.9 | 0.150 |
Beta blocker | 65 | 92.9 | 1867 | 87.6 | 0.187 |
Calcium blocker | 2 | 2.9 | 127 | 6 | 0.434 |
Lipid lowering agent | 68 | 97.1 | 1720 | 80.7 | <.001 |
Spironolactone | 9 | 12.9 | 115 | 5.4 | 0.008 |
ACE-Inhibitor or ARB | 62 | 88.6 | 1709 | 80.2 | 0.082 |