|
Age (years)
|
70
|
(60.8 ± 8.8)
|
2131
|
(58.5 ± 11)
|
0.097
|
|
Women
|
17
|
24.3
|
467
|
21.9
|
0.637
|
|
Race White
|
70
|
100
|
1693
|
79.4
|
<.001
|
|
Clinical history
| | | | | |
|
Angina
|
15
|
21.4
|
480
|
22.5
|
0.829
|
|
Myocardial Infarction
|
3
|
4.3
|
244
|
11.5
|
0.080
|
|
Percutaneous intervention
|
4
|
5.7
|
101
|
4.7
|
0.574
|
|
Congestive heart failure
|
1
|
1.4
|
51
|
2.4
|
1.000
|
|
Hypertension
|
36
|
51.4
|
1035
|
48.6
|
0.638
|
|
Diabetes
|
10
|
14.3
|
444
|
20.8
|
0.183
|
|
Insulin use
|
6
|
8.6
|
118
|
5.5
|
0.279
|
|
Hypercholesterolemia
|
31
|
44.3
|
1111
|
52.2
|
0.195
|
|
Stroke
|
4
|
5.7
|
59
|
2.8
|
0.138
|
|
Cerebrovascular disease
|
5
|
7.1
|
77
|
3.6
|
0.125
|
|
Peripheral vascular disease
|
1
|
1.4
|
82
|
3.9
|
0.519
|
|
Current Smoker
|
25
|
35.7
|
834
|
39.1
|
0.564
|
|
Family history CAD
|
29
|
41.4
|
854
|
40.1
|
0.820
|
|
Days from MI to randomization - median {IQR}
|
70
|
21{16–26}
|
2131
|
8{5–16}
|
<.001
|
|
Index myocardial infarction
| | | | | |
|
Received thrombolytics
|
1
|
1.4
|
423
|
19.9
|
<.001
|
|
STE / Q wave / R loss
|
58
|
82.9
|
1849
|
86.8
|
0.344
|
|
Killip Class II-IV
|
11
|
15.7
|
406
|
19.1
|
0.473
|
|
Ejection Fraction
|
70
|
(46.3 ± 9.7)
|
2115
|
(47.8 ± 11.1)
|
0.275
|
|
Rales
|
1
|
1.4
|
136
|
6.4
|
0.125
|
|
Clinical measures
| | | | | |
|
Estimated GFR <60 ml/min/1.73 m2
|
8
|
11.4
|
305
|
14.6
|
0.453
|
|
Glucose > =126 mg/dl
|
8
|
11.6
|
556
|
28.8
|
0.002
|
|
BMI (kg/m2)
|
69
|
(26.7 ± 3.6)
|
2118
|
(28.6 ± 5.1)
|
0.003
|
|
Heart rate (bpm)
|
70
|
(69.3 ± 9.8)
|
2128
|
(71.9 ± 12)
|
0.076
|
|
Systolic blood pressure (mmHg)
|
70
|
(120.4 ± 11.9)
|
2129
|
(120.8 ± 18.1)
|
0.831
|
|
Angiography
| | | | | |
|
Infarct-related artery (IRA) –LAD
|
19
|
27.1
|
774
|
36.3
|
. 0.267
|
|
Infarct-related artery (IRA) –Lcx
|
11
|
15.7
|
324
|
15.2
|
|
Infarct-related artery (IRA) –RCA
|
40
|
57.1
|
1033
|
48.5
|
|
Multivessel Disease
|
21
|
30.4
|
358
|
16.9
|
0.004
|
|
Collaterals
|
64
|
92.8
|
1858
|
88.3
|
0.256
|
|
Medications
| | | | | |
|
Aspirin
|
68
|
97.1
|
2037
|
95.6
|
0.767
|
|
Thienopyridine
|
42
|
60
|
1287
|
60.4
|
0.947
|
|
Warfarin
|
3
|
4.3
|
212
|
9.9
|
0.150
|
|
Beta blocker
|
65
|
92.9
|
1867
|
87.6
|
0.187
|
|
Calcium blocker
|
2
|
2.9
|
127
|
6
|
0.434
|
|
Lipid lowering agent
|
68
|
97.1
|
1720
|
80.7
|
<.001
|
|
Spironolactone
|
9
|
12.9
|
115
|
5.4
|
0.008
|
|
ACE-Inhibitor or ARB
|
62
|
88.6
|
1709
|
80.2
|
0.082
|
