Figure 4From: The role of the Hsp90/Akt pathway in myocardial calpain-induced caspase-3 activation and apoptosis during sepsis The effects of treatment with 17AAG (Hsp90 inhibitor) on Akt activity and wortmannin (PI3K inhibitor) on caspase-3 activation are depicted. Mice were treated with either 17-AAG or wortmannin (3 mg/kg, i.p). Four hours after administration, the activation of Akt and caspase-3 was detected. * P < 0.05 vs. sham (n = 5).Back to article page