|
•
|
Fontan/TCPC operated
|
|
•
|
Expected clinical stability > 3 months, evaluated by investigator from clinical record
|
|
Exclusion criteria
|
|
•
|
Age < 12 years
|
|
•
|
Severe heart failure (NYHA-class IV)
|
|
•
|
Oxygen saturation < 85% at rest
|
|
•
|
Pre-existing liver condition (transaminases 2x > upper reference limit)
|
|
•
|
Renal failure (creatinin > 150 mmol/l)
|
|
•
|
Restrictive Fontan circuit
|
|
•
|
History of work induced severe arrhythmia
|
|
•
|
Systolic blood pressure below 80% of reference (< 88 mmHg)
|
|
•
|
Use of any of following drugs: Fluconazole, Ketoconazole, CyclosporineA, Lopinavir, Ritonavir, Rifampicin, Carbamazepine and Phenytoin
|
|
•
|
Severe extra-cardiac condition e.g. neurological impairment
|
|
•
|
For women: Positive HCG or no use of contraception*
|
|
•
|
History of low compliance
|
