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Table 2 Association of the AGT gene variants with cardiovascular risk traits

From: Association of the angiotensinogen gene polymorphism with atherosclerosis and its risk traits in the Saudi population

Variant Allele/Genotype CON Cases O.R.(95%C.I.) P-value
Hypertension   N = 1596 N = 3521   
rs2067853G > A G 0.681 0.711 1.15(1.04-1.28) 0.007*
  GG 0.870 0.906 1.44(1.17-1.78) 0.001**
rs7079G > T G 0.683 0.712 1.14(1.03-1.27) 0.012
  GG 0.879 0.915 1.49(1.20-1.85) <0.0001**
rs699G > A G 0.560 0.602 1.19(1.08-1.31) <0.0001**
(p.M268T) GG 0.791 0.821 1.21(1.03-1.44) 0.024
  AG + GG 0.328 0.383 1.26(1.10-1.46) 0.001**
rs3789679G > A A 0.028 0.042 1.51(1.14-1.99) 0.004*
AA 0.005 0.012 2.70(1.07-6.83) 0.036
GA + AA 0.052 0.072 1.41(1.05-1.90) 0.022
rs2148582G > A G 0.563 0.587 1.10(1.00-1.21) 0.051
GG 0.786 0.828 1.31(1.11-1.55) 0.002*
rs5051T > C C 0.571 0.599 1.12(1.02-1.24) 0.02
  TC + CC 0.800 0.843 1.32(1.13-1.60) 0.001**
Myocardial infarction   N = 1584 N = 3033   
rs2067853G > A GG 0.889 0.902 1.16(1.01-1.33) 0.042
rs7079G > T GG 0.898 0.911 1.15(1.00-1.33) 0.054
rs1926723T > C T 0.961 0.969 1.25(0.99-1.57) 0.063
rs699G > A G 0.573 0.602 1.13(1.03-1.23) 0.007*
GG 0.803 0.820 1.20(1.00-1.25) 0.047
AG + GG 0.343 0.384 1.20(1.09-1.31) <0.0001**
rs5051T > C TC + CC 0.822 0.838 1.12(1.00-1.25) 0.051
Obesity   N = 3342 N = 1721   
rs4762G > A G 0.887 0.903 1.19(1.03-1.37) 0.019
(p.M207T) AG + GG 0.192 0.167 0.85(0.72-0.99) 0.040
rs3789679G > A A 0.032 0.050 1.59(1.28-1.98) <0.0001**
AA 0.008 0.015 2.00(1.12-3.58) 0.019
  GA + AA 0.056 0.085 1.57(1.24-2.00) <0.0001**
  1. The table compares the AGT allele/genotype frequencies (as proportions), odd ratios (O.R.), 95% confidence levels (95% C. I.) and the significance levels of the associations in hypertension, myocardial infarction and obesity versus their respective angiographed controls. The letter N represents the population size. *P < 0.01, **P < 0.001 by χ2 test.