Association of the angiotensinogen gene polymorphism with atherosclerosis and its risk traits in the Saudi population

Table 2 Association of the AGT gene variants with cardiovascular risk traits

Variant	Allele/Genotype	CON	Cases	O.R.(95%C.I.)	P-value
Hypertension		N = 1596	N = 3521
rs2067853G > A	G	0.681	0.711	1.15(1.04-1.28)	0.007*
	GG	0.870	0.906	1.44(1.17-1.78)	0.001**
rs7079G > T	G	0.683	0.712	1.14(1.03-1.27)	0.012
	GG	0.879	0.915	1.49(1.20-1.85)	<0.0001**
rs699G > A	G	0.560	0.602	1.19(1.08-1.31)	<0.0001**
(p.M268T)	GG	0.791	0.821	1.21(1.03-1.44)	0.024
	AG + GG	0.328	0.383	1.26(1.10-1.46)	0.001**
rs3789679G > A	A	0.028	0.042	1.51(1.14-1.99)	0.004*
	AA	0.005	0.012	2.70(1.07-6.83)	0.036
	GA + AA	0.052	0.072	1.41(1.05-1.90)	0.022
rs2148582G > A	G	0.563	0.587	1.10(1.00-1.21)	0.051
rs2148582G > A	GG	0.786	0.828	1.31(1.11-1.55)	0.002*
rs5051T > C	C	0.571	0.599	1.12(1.02-1.24)	0.02
	TC + CC	0.800	0.843	1.32(1.13-1.60)	0.001**
Myocardial infarction		N = 1584	N = 3033
rs2067853G > A	GG	0.889	0.902	1.16(1.01-1.33)	0.042
rs7079G > T	GG	0.898	0.911	1.15(1.00-1.33)	0.054
rs1926723T > C	T	0.961	0.969	1.25(0.99-1.57)	0.063
rs699G > A	G	0.573	0.602	1.13(1.03-1.23)	0.007*
	GG	0.803	0.820	1.20(1.00-1.25)	0.047
	AG + GG	0.343	0.384	1.20(1.09-1.31)	<0.0001**
rs5051T > C	TC + CC	0.822	0.838	1.12(1.00-1.25)	0.051
Obesity		N = 3342	N = 1721
rs4762G > A	G	0.887	0.903	1.19(1.03-1.37)	0.019
(p.M207T)	AG + GG	0.192	0.167	0.85(0.72-0.99)	0.040
rs3789679G > A	A	0.032	0.050	1.59(1.28-1.98)	<0.0001**
rs3789679G > A	AA	0.008	0.015	2.00(1.12-3.58)	0.019
	GA + AA	0.056	0.085	1.57(1.24-2.00)	<0.0001**

The table compares the AGT allele/genotype frequencies (as proportions), odd ratios (O.R.), 95% confidence levels (95% C. I.) and the significance levels of the associations in hypertension, myocardial infarction and obesity versus their respective angiographed controls. The letter N represents the population size. *P < 0.01, **P < 0.001 by χ² test.

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