Table 6 Subgroup analysis of the primary endpoint
Subgroup | Closure Trial | PC Trial | Respect Trial | Random Effects Model | |||||
|---|---|---|---|---|---|---|---|---|---|
HR | 95%CI | HR | 95%CI | HR | 95%CI | HR | 95% CI | p-value | |
Atrial Septal Aneurysm | |||||||||
Yes | 0.78 | 0.30, 2.13 | 2.09 | 0.38, 11.4 | 0.19 | 0.04, 0.87 | 0.67 | 0.21, 2.16 | 0.50 |
No | 0.81 | 0.42, 1.59 | 0.32 | 0.09, 1.18 | 0.89 | 0.31, 2.54 | 0.71 | 0.43, 1.19 | 0.19 |
Age | |||||||||
≤ 45 | NA | NA | 0.16 | 0.02, 1.31 | 0.70 | 0.19, 2.60 | 0.42 | 0.11, 1.66 | 0.22 |
> 45 | NA | NA | 1.22 | 0.37, 3.99 | 0.41 | 0.14, 1.17 | 0.68 | 0.23, 2.00 | 0.48 |
Sex | |||||||||
Male | 0.50 | 0.20, 1.22 | NA | NA | 0.45 | 0.15, 1.31 | 0.48 | 0.24, 0.96 | 0.04 |
Female | 1.13 | 0.55, 2.34 | NA | NA | 0.57 | 0.16, 2.02 | 0.96 | 0.51, 1.79 | 0.89 |
Shunt Size | |||||||||
None, trace or moderate | 0.78 | 0.40, 1.50 | NA | NA | 1.03 | 0.35, 3.08 | 0.84 | 0.48, 1.49 | 0.56 |
Substantial | 0.72 | 0.15, 3.57 | NA | NA | 0.18 | 0.04, 0.81 | 0.35 | 0.09, 1.39 | 0.14 |