Chromosome 1p13 genetic variants antagonize the risk of myocardial infarction associated with high ApoB serum levels

Table 2 Distribution across the genotype strata of total-, LDL-cholesterol and ApoB serum levels and effect of rs599839 and rs646776 on total-, LDL-cholesterol and ApoB serum levels in the SHEEP study

		Total-Chol (N = 2646)	P	LDL-Chol (N = 2599)	P	ApoB (N = 2643)	P
rs599839	AA	6.0 (5.3-6.7)		4.1 (3.4-4.7)		1.5 (1.3-1.8)
	AG	5.8 (5.2-6.6)		3.9 (3.3-4.6)		1.5 (1.3-1.7)
	GG	5.8 (4.9-6.5)	0.003	3.9 (3.2-4.4)	0.007	1.4 (1.2-1.7)	0.03
B (SE)		−0.65 (0.019)	0.001	−0.62 (0.020)	0.002	−0.65(0.019)	0.001
rs646776	TT	6.0 (5.3-6.7)		4.1 (3.5-4.7)		1.5 (1.3-1.8)
	CT	5.9 (5.2-6.7)		3.9 (3.3-4.6)		1.5 (1.2-1.7)
	CC	5.8 (5.1-6.4)	0.04	3.9 (3.2-4.4)	0.0003	1.4 (1.2-1.7)	0.00001
B (SE)		−0.63 (0.019)	0.001	−0.82 (0.020)	<0.0001	−0.83 (0.020)	<0.0001

Total- and LDL-cholesterol serum levels are expressed in mmol/L and ApoB serum levels in g/L. Median ± IQRT are reported at each genotype strata. The effect of each SNP on total-, LDL-cholesterol and ApoB serum levels is reported in the last row of each section and expressed as beta coefficient (b) along with the standard error (SE).

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