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Table 2 Distribution across the genotype strata of total-, LDL-cholesterol and ApoB serum levels and effect of rs599839 and rs646776 on total-, LDL-cholesterol and ApoB serum levels in the SHEEP study

From: Chromosome 1p13 genetic variants antagonize the risk of myocardial infarction associated with high ApoB serum levels

   Total-Chol (N = 2646) P LDL-Chol (N = 2599) P ApoB (N = 2643) P
rs599839 AA 6.0 (5.3-6.7)   4.1 (3.4-4.7)   1.5 (1.3-1.8)  
  AG 5.8 (5.2-6.6)   3.9 (3.3-4.6)   1.5 (1.3-1.7)  
  GG 5.8 (4.9-6.5) 0.003 3.9 (3.2-4.4) 0.007 1.4 (1.2-1.7) 0.03
B (SE)   −0.65 (0.019) 0.001 −0.62 (0.020) 0.002 −0.65(0.019) 0.001
rs646776 TT 6.0 (5.3-6.7)   4.1 (3.5-4.7)   1.5 (1.3-1.8)  
  CT 5.9 (5.2-6.7)   3.9 (3.3-4.6)   1.5 (1.2-1.7)  
  CC 5.8 (5.1-6.4) 0.04 3.9 (3.2-4.4) 0.0003 1.4 (1.2-1.7) 0.00001
B (SE)   −0.63 (0.019) 0.001 −0.82 (0.020) <0.0001 −0.83 (0.020) <0.0001
  1. Total- and LDL-cholesterol serum levels are expressed in mmol/L and ApoB serum levels in g/L. Median ± IQRT are reported at each genotype strata. The effect of each SNP on total-, LDL-cholesterol and ApoB serum levels is reported in the last row of each section and expressed as beta coefficient (b) along with the standard error (SE).