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Table 1 Selected average parameters from pressure-volume loop study in the C3H/HeN and C3H/HeJ groups

From: Novel Toll-like receptor-4 deficiency attenuates trastuzumab (Herceptin) induced cardiac injury in mice

Variables HeN HeJ *P value
  Before Tras. After Tras. Before Tras. After Tras.  
Heart rate (bpm) 449.67 ± 2.29 392.44 ± 16.47 452 ± 16 448 ± 31 <0.05
End-systolic Volume (uL) 13.42 ± 0.25 45.23 ± 0.42 14.04 ± 0.38 21.28 ± 0.60 <0.05
End-diastolic Volume(uL) 35.25 ± 0.36 63.77 ± 0.51 34.90 ± 0.55 41.40 ± 0.54 <0.05
End-systolic pressure(mmHg) 123.8 ± 0.47 179.35 ± 3.40 122.3 ± 1.03 139.22 ± 1.04 <0.05
End-diastolic pressure(mmHg) 8.2 ± 0.58 97.40 ± 3.53 7.97 ± 0.09 15.28 ± 0.17 <0.05
Ejection Fraction (%) 61.91 ± 8.9 29.06 ± 1.05 63.14 ± 2.17 52.17 ± 2.56 <0.05
Cardiac Output (ml/min) 10.44 ± 4.54 5.03 ± 0.57 11.01 ± 0.30 9.84 ± 0.28 <0.05
  1. *Data are expressed as mean ± SEM; n = 8 in each group P value < 0.05.