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Table 3 Hazard ratios of renal endpoints by number of cardiovascular risk factor treatment targets achieved

From: Cardiovascular risk factor treatment targets and renal complications in high risk vascular patients: a cohort study

 

All

Clinically Manifest Vascular Disease

Diabetes

 

HR

(95% CI)

p for trends

HR

95% CI

p for trends

HR

95% CI

p for trends

n

7208

  

4859

  

1759

  

number of events

81

  

52

  

28

  

Renal endpoint

         

Model 1 (crude)

         

Targets achieved

         

   ≤ 1

1.00

 

0.001

1.00

 

0.0001

1.00

 

0.704

   2

0.59

(0.34, 1.02)

 

0.51

(0.26, 1.00)

 

0.69

(0.27, 1.81)

 

   3

0.36

(0.18, 0.71)

 

0.23

(0.09, 0.59)

 

1.09

(0.39, 3.05)

 

   4

0.37

(0.12, 1.19)

 

0.29

(0.07, 1.22)

 

0.99

(0.29, 3.47)

 

   ≥ 5

0.22

(0.03, 1.59)

 

0

0

 

0

0

 

Model 2 adjusted

a

  

b

  

c

  

Targets achieved

         

   ≤ 1

1.00

 

0.018

1.00

 

0.021

1.00

 

0.174

   2

0.49

(0.28, 0.86)

 

0.58

(0.29, 1.14)

 

0.37

(0.13, 1.00)

 

   3

0.54

(0.27, 1.09)

 

0.38

(0.15, 0.99)

 

0.62

(0.22, 1.80)

 

   4

0.46

(0.14, 1.51)

 

0.64

(0.15, 2.69)

 

0.54

(0.15, 1.99)

 

   ≥ 5

0.42

(0.06, 3.11)

 

0

0

 

0

0

 

Model 3 adjusted d

         

Targets achieved

         

   ≤ 1

1.00

 

0.013

1.00

 

0.018

1.00

 

0.107

   2

0.46

(0.26, 0.82)

 

0.56

(0.28, 1.12)

 

0.28

(0.10, 0.79)

 

   3

0.51

(0.26, 1.03)

 

0.36

(0.14, 0.95)

 

0.39

(0.12, 1.26)

 

   4

0.49

(0.15, 1.60)

 

0.63

(0.15, 2.67)

 

0.56

(0.16, 2.01)

 

   ≥ 5

0.37

(0.05, 2.76)

 

0

0

 

0

0

 

Risk factors e

         

SBP (per mmHg)

1.02

(1.01, 1.03)

 

1.02

(1.01, 1.03)

 

1.03

(1.01, 1.05)

 

LDL (per mmol/L)

1.26

(1.04, 1.53)

 

1.31

(1.02, 1.68)

 

1.21

(0.83, 1.75)

 

Treatment for albuminuria

0.90

(0.57, 1.43)

 

0.97

(0.55, 1.70)

 

0.58

(0.24, 1.39)

 

HbA1c (per %)

1.18

(1.01, 1.38)

 

1.20

(0.96, 1.49)

 

1.44

(1.12, 1.84)

 
  1. aadjusted for hypertension, albuminuria, eGFR and haemoglobin levels
  2. badjusted for hypertension, albuminuria and eGFR levels
  3. cadjusted for eGFR and haemoglobin levels
  4. dadjusted for Model 2 + age and sex
  5. eadjusted for age, sex, hypertension, albuminuria, eGFR and haemoglobin levels
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