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Table 3 Hazard ratios of renal endpoints by number of cardiovascular risk factor treatment targets achieved

From: Cardiovascular risk factor treatment targets and renal complications in high risk vascular patients: a cohort study

  All Clinically Manifest Vascular Disease Diabetes
  HR (95% CI) p for trends HR 95% CI p for trends HR 95% CI p for trends
n 7208    4859    1759   
number of events 81    52    28   
Renal endpoint          
Model 1 (crude)          
Targets achieved          
   ≤ 1 1.00   0.001 1.00   0.0001 1.00   0.704
   2 0.59 (0.34, 1.02)   0.51 (0.26, 1.00)   0.69 (0.27, 1.81)  
   3 0.36 (0.18, 0.71)   0.23 (0.09, 0.59)   1.09 (0.39, 3.05)  
   4 0.37 (0.12, 1.19)   0.29 (0.07, 1.22)   0.99 (0.29, 3.47)  
   ≥ 5 0.22 (0.03, 1.59)   0 0   0 0  
Model 2 adjusted a    b    c   
Targets achieved          
   ≤ 1 1.00   0.018 1.00   0.021 1.00   0.174
   2 0.49 (0.28, 0.86)   0.58 (0.29, 1.14)   0.37 (0.13, 1.00)  
   3 0.54 (0.27, 1.09)   0.38 (0.15, 0.99)   0.62 (0.22, 1.80)  
   4 0.46 (0.14, 1.51)   0.64 (0.15, 2.69)   0.54 (0.15, 1.99)  
   ≥ 5 0.42 (0.06, 3.11)   0 0   0 0  
Model 3 adjusted d          
Targets achieved          
   ≤ 1 1.00   0.013 1.00   0.018 1.00   0.107
   2 0.46 (0.26, 0.82)   0.56 (0.28, 1.12)   0.28 (0.10, 0.79)  
   3 0.51 (0.26, 1.03)   0.36 (0.14, 0.95)   0.39 (0.12, 1.26)  
   4 0.49 (0.15, 1.60)   0.63 (0.15, 2.67)   0.56 (0.16, 2.01)  
   ≥ 5 0.37 (0.05, 2.76)   0 0   0 0  
Risk factors e          
SBP (per mmHg) 1.02 (1.01, 1.03)   1.02 (1.01, 1.03)   1.03 (1.01, 1.05)  
LDL (per mmol/L) 1.26 (1.04, 1.53)   1.31 (1.02, 1.68)   1.21 (0.83, 1.75)  
Treatment for albuminuria 0.90 (0.57, 1.43)   0.97 (0.55, 1.70)   0.58 (0.24, 1.39)  
HbA1c (per %) 1.18 (1.01, 1.38)   1.20 (0.96, 1.49)   1.44 (1.12, 1.84)  
  1. aadjusted for hypertension, albuminuria, eGFR and haemoglobin levels
  2. badjusted for hypertension, albuminuria and eGFR levels
  3. cadjusted for eGFR and haemoglobin levels
  4. dadjusted for Model 2 + age and sex
  5. eadjusted for age, sex, hypertension, albuminuria, eGFR and haemoglobin levels