Table 2 Thirty-day outcomes of randomized clinical trials comparing an invasive treatment strategy to a delayed invasive or ischemia-guided approach among STEMI patients treated with fibrinolysis.

PRAGUE[16]

Death/Reinfarction/Stroke*

15/100

23/99

0.65 (0.36, 1.16)

0.14^‡

Death

12/100

14/99

0.85 (0.41, 1.74)

0.66^‡

Reinfarction

7/100

10/99

0.69 (0.27, 1.75)

0.43^‡

Stroke

3/100

1/99

2.97 (0.31, 28.1)

0.62^‡

SIAM-3[18]^†

CABG

0/82

0/81

-

1.00

TLR

2/82

2/81

0.99 (0.14, 6.84)^‡

0.685

Ischemic Events

3/82

20/81

0.15 (0.05, 0.48)^‡

0.01

Reinfarction

2/82

2/81

0.99 (0.14, 6.84)^‡

0.685

Death

4/82

8/81

0.49 (0.15, 1.58)^‡

0.179

Death/Reinfarction

6/82

10/81

0.59 (0.23, 1.55)^‡

0.208

Death/Reinfarction/TLR

6/82

11/81

0.54 (0.21, 1.39)^‡

0.146

Death/Reinfarction/TLR/Ischemic Events

7/82

25/81

0.28 (0.13, 0.60)^‡

0.001

GRACIA-1[19]

Death

6/248

6/251

1.01 (0.33, 3.10)

0.84

Non-Fatal Reinfarction

3/248

4/251

0.76 (0.17, 3.36)

0.98

Death/Non-Fatal Reinfarction

9/248

9/251

1.01 (0.41, 2.51)

0.97

Death/Non-Fatal Reinfarction/Revascularization

12/248

16/251

0.76 (0.37, 1.57)

0.46

CAPITAL-AMI[20]

Death/Recurrent MI/Recurrent Unstable Ischemia, Stroke

8/86

18/84

0.43 (0.20, 0.93)

0.03

Death

2/86

3/84

0.64 (0.11, 3.75)

0.68

Reinfarction

4/86

11/84

0.35 (0.12, 1.06)

0.06

Recurrent Unstable Ischemia

6/86

15/84

0.39 (0.16, 0.95)

0.04

Stroke

1/86

1/84

0.97 (0.61, 15.18)

1.00

Death/Reinfarction/Stroke

6/86

14/84

0.41 (0.17, 1.03)

0.06

Leipzig[23]

Death

2/82

4/82

0.50 (0.09, 2.65)^‡

0.68^‡

Non-Fatal Reinfarction

3/82

7/82

0.43 (0.11, 1.60)^‡

0.33^‡

Stroke

0/82

1/82

-

1.00^‡

Major bleeding

4/82

5/82

0.80 (0.22, 2.87)^‡

1.00^‡

Death/Reinfarction/Stroke/Major Bleeding

9/82

17/82

0.52 (0.23, 1.18)

0.13^¥

WEST[25]

Death/Reinfarction/Refractory Ischemia/CHF/Cardiogenic Shock/Major Ventricular Arrhythmia*

25/104

25/100

0.96 (0.59, 1.56) ^‡

0.87^‡

Death

1/104

4/100

0.24 (0.03, 2.11) ^‡

0.21^‡

Reinfarction

6/104

9/100

0.64 (0.24, 1.74) ^‡

0.38^‡

CHF

15/104

15/100

0.96 (0.50, 1.86)^‡

0.91^‡

Cardiogenic Shock

4/104

6/100

0.64 (0.19, 2.20)^‡

0.53^‡

Refractory Ischemia

3/104

0/100

-

0.25^‡

Major Ventricular Arrhythmias

1/104

1/100

0.96 (0.06, 15.2)^‡

1.00^‡

CARESS-AMI[26]

Death/Reinfarction/Refractory Ischemia*

13/297

32/300

0.41 (0.22, 0.77)^‡

0.005

Death

9/297

14/300

0.65 (0.29, 1.48)^‡

0.40

Reinfarction

4/297

6/300

0.67 (0.19, 2.36)^‡

0.75

Refractory Ischemia

1/297

12/300

0.08 (0.01, 0.64)^‡

0.003

TRANSFER AMI[27]

Death/Reinfarction/Recurrent Ischemia/New or Worsening CHF/Cardiogenic Shock*

59/536

90/522

0.64 (0.47, 0.87)

0.004

Death

24/536

18/522

1.30 (0.71, 2.36)

0.39

Reinfarction

18/536

30/522

0.57 (0.33, 1.04)

0.06

Death/Reinfarction

38/536

47/522

0.79 (0.52, 1.19)

0.25

Recurrent Ischemia

1/536

11/522

0.09 (0.01, 0.68)

0.003

Death/Reinfarction/Recurrent Ischemia

39/536

58/522

0.65 (0.44, 0.96)

0.03

New or Worsening CHF

16/536

29/522

0.54 (0.30, 0.98)

0.04

Cardiogenic Shock

24/536

16/522

1.46 (0.79, 2.72)

0.23

NORDISTEMI[28]

Death/Reinfarction/Stroke/New Ischemia

14/134

28/132

0.49 (0.27, 0.89)^‡

0.02^‡

Death/Reinfarction/Stroke

6/134

13/132

0.45 (0.18, 1.16)^‡

0.09^‡

Death

3/134

3/132

0.99 (0.20, 4.79)^‡

1.00^‡

Reinfarction

2/134

7/132

0.28 (0.06, 1.33)^‡

0.10^‡

Stroke

3/134

5/132

0.59 (0.14, 2.42)^‡

0.50^‡

Recurrent Ischemia

8/134

16/132

0.49 (0.22, 1.11)^‡

0.08^‡