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Table 2 CTA diagnostic performance measures

From: A systematic review of the clinical effectiveness of 64-slice or higher computed tomography angiography as an alternative to invasive coronary angiography in the investigation of suspected coronary artery disease

Analysis level No. of included studies a Sensitivity % (95% CI) Specificity % (95% CI) PPV Median (range) NPV Median (range) Diagnostic accuracy Median (range)
Patient: base case analysis 18 98.2 (97.4-98.8) 81.6 (79.0-84.0) 90.5 (76-100) 99.0 (83-100) 92.0 (80-100)
Patient: alternative analysis 22 98.0 (97.2-98.6) 83.2 (81.1-85.2) 89.0 (63-100) 98.0 (83-100) 92.0 (80-100)
Vessels: all 17 94.9 (93.9-95.8) 89.5 (88.8-90.2) 75.0 (53-95) 99.0 (93-100) 91.5 (74-98)
   RCA 8 94.8 (92.0-96.9) 91.0 (89.0-92.7) 84.0 (73-94) 98.5 (95-100) 94.5 (84-99)
   LM 8 95.7 (85.2-99.5) 97.1 (95.7-98.1) 89.0 (24-100) 100.0 (98-100) 99.0 (91-100)
   LAD 7 97.4 (95.3-98.8) 84.5 (82.1-86.7) 78.0 (57-95) 99.0 (95-100) 93.0 (72-99)
   CX 8 94.1 (90.7-96.6) 89.6 (87.7-91.3) 78.5 (52-90) 99.5 (95-100) 94.0 (75-99)
Segments: all 17 91.3 (90.2-92.2) 94.0 (93.7-94.2) 69.0 (44-86) 99.0 (98-100) 95.5 (90-99)
  1. CI, confidence interval; CX, circumflex; LAD, left anterior descending; LM, left main; NPV, negative predictive value; PPV, positive predictive value; RCA, right coronary artery
  2. a Maximum number of included studies from which data were drawn to calculate diagnostic performance measures