Intimal Hyperplasia in Balloon Dilated Coronary Arteries is Reduced by Local Delivery of the NO Donor, SIN-1 Via a cGMP-Dependent Pathway

Table 1 Angiographic characteristics

Diameter measurements	ODQ+ SIN-1 mm n = 11	SIN-1 mm n = 11	NaCl Control mm n = 5	P -value
Pre- treatment (A)	2.62 ± 0.36	2.76 ± 0.35	2.81 ± 0.41	ns
After treatment (B)	2.77 ± 0.38	2.93 ± 0.34	3.10 ± 0.37	ns
After 8 weeks (C)	3.17 ± 0.35	3.53 ± 0.30	3.07 ± 0.25	< 0.01
Age-corrected at 8 weeks (D)	2.60 ± 0.32	3.12 ± 0.41	2.62 ± 0.29	< 0.01
Late Loss (B-D)	0.21 ± 0,30	-0.19 ± 0,51	0.48 ± 0,31	< 0,05

Legend to table 1: Age related growth of the arteries was similar for segments treated either with SIN-1 or ODQ + SIN-1 or to controls. With or without age correction, SIN-1 treated arteries had after 8 weeks significantly larger diameter compared to ODQ + SIN-1 or control segments. Data presented as mean ± SD. One way ANOVA test.

ISSN: 1471-2261