Table 3 Parametric comparisons of cardiac parameters after 4 weeks of exposure to isoproterenol and treatment with P188 in BL10 and mdx mice.
Measurement | Group | N | Mean ± SD | Overall p-value | Significantly different groups |
|---|---|---|---|---|---|
SF% | BL10 - Untx | 3 | 33.34 ± 1.15 | BL10-Untx vs. BL10-Iso (p = 0.019) BL10-Untx vs. MDX-Iso+P188 (p = 0.017) | |
BL10 - Iso | 7 | 45.13 ± 4.71 | BL10-Iso vs. MDX-Untx (p < 0.001) | ||
MDX - Untx | 6 | 29.64 ± 3.11 | <0.0001 | BL10-Iso vs. MDX-Iso (p = 0.006) | |
MDX - Iso | 9 | 35.37 ± 5.77 | MDX-Untx vs. MDX-Iso+P188 (p < 0.001) | ||
MDX - Iso + P188 | 5 | 45.97 ± 6.23 | MDX-Iso vs. MDX-Iso+P188 (p = 0.007) | ||
EF% | BL10 - Untx | 3 | 59.15 ± 1.89 | ||
BL10 - Iso | 7 | 69.72 ± 5.56 | |||
MDX - Untx | 6 | 57.25 ± 7.78 | 0.0027 | BL10-Iso vs. MDX-Untx (p = 0.020) | |
MDX - Iso | 9 | 57.84 ± 4.56 | BL10-Iso vs. MDX-Iso (p = 0.013) | ||
MDX - Iso + P188 | 5 | 68.28 ± 9.89 | |||
LVID (d) (mm) | BL10 - Untx | 3 | 4.03 ± 0.12 | ||
BL10 - Iso | 7 | 3.73 ± 0.13 | BL10-Untx vs. MDX-Iso+P188 (p = 0.002) | ||
MDX - Untx | 6 | 4.02 ± 0.07 | 0.0001 | BL10-Iso vs. MDX-Iso (p = 0.029) | |
MDX - Iso | 9 | 3.54 ± 0.34 | MDX-Untx vs. MDX-Iso (p = 0.0125) | ||
MDX - Iso + P188 | 5 | 3.27 ± 0.32 | MDX-Untx vs. MDX-Iso+P188 (p < 0.001) | ||
LVPW (d) (mm) | BL10 - Untx | 3 | 0.62 ± 0.10 | ||
BL10 - Iso | 7 | 0.80 ± 0.08 | BL10-Untx vs. BL10-Iso (p = 0.022) | ||
MDX - Untx | 6 | 0.59 ± 0.01 | <0.0001 | BL10-Untx vs. MDX-Iso (p = 0.001) BL10-Untx vs. MDX-Iso+P188 (p = 0.004) | |
MDX - Iso | 9 | 0.86 ± 0.09 | BL10-Iso vs. MDX-Untx (p < 0.001) | ||
MDX - Iso + P188 | 5 | 0.84 ± 0.07 | MDX-Untx vs. MDX-Iso (p < 0.001) MDX-Untx vs. MDX-Iso+P188 (p < 0.001) | ||
LV mass (mg) | BL10 - Untx | 3 | 75.16 ± 7.16 | ||
BL10 - Iso | 7 | 98.33 ± 11.06 | |||
MDX - Untx | 6 | 76.88 ± 3.36 | 0.0019 | BL10-Untx vs. BL10-Iso (p = 0.012) | |
MDX - Iso | 9 | 87.22 ± 11.08 | BL10-Iso vs. MDX-Untx (p = 0.003) | ||
MDX - Iso + P188 | 5 | 89.15 ± 7.54 | |||
AoV vel (mm/s) | BL10 - Untx | 3 | 1004 ± 87 | ||
BL10 - Iso | 7 | 1077 ± 186 | |||
MDX - Untx | 6 | 1105 ± 117 | 0.0388 | None | |
MDX - Iso | 9 | 1274 ± 159 | |||
MDX - Iso + P188 | 5 | 1253 ± 183 | |||
Systolic BP (mmHg) | BL10 - Untx | 3 | 94 ± 5 | ||
BL10 - Iso | 7 | 99 ± 8 | BL10-Untx vs. MDX-Iso (p = 0.011) | ||
MDX - Untx | 3 | 87 ± 8 | 0.0001 | BL10-Iso vs. MDX-Iso (p < 0.001) | |
MDX - Iso | 9 | 73 ± 11 | BL10-Iso vs. MDX-Iso+P188 (p = 0.006) | ||
MDX - Iso + P188 | 4 | 77 ± 6 | |||
Diastolic BP (mmHg) | BL10 - Untx | 3 | 50 ± 9 | ||
BL10 - Iso | 7 | 85 ± 8 | |||
MDX - Untx | 3 | 67 ± 3 | <0.0001 | BL10-Untx vs. BL10-Iso (p < 0.001) BL10-Iso vs. MDX-Untx (p = 0.022) | |
MDX - Iso | 9 | 61 ± 8 | BL10-Iso vs. MDX-Iso (p < 0.001) | ||
MDX - Iso + P188 | 4 | 58 ± 3 | BL10-Iso vs. MDX-Iso+P188 (p < 0.001) | ||
Mean BP (mmHg) | BL10 - Untx | 3 | 64 ± 7 | ||
BL10 - Iso | 7 | 89 ± 7 | BL10-Untx vs. BL10-Iso (p < 0.001) | ||
MDX - Untx | 3 | 73 ± 4 | <0.0001 | BL10-Iso vs. MDX-Untx (p = 0.018) | |
MDX - Iso | 9 | 63 ± 7 | BL10-Iso vs. MDX-Iso (p < 0.001) | ||
MDX - Iso + P188 | 4 | 64 ± 2 | BL10-Iso vs. MDX-Iso+P188 (p < 0.001) |