Ventricular-arterial uncoupling in heart failure with preserved ejection fraction after myocardial infarction in dogs - invasive versus echocardiographic evaluation

Table 2 PV loops data

	Control (n = 6)	Post MI (n = 17)	P value
Global cardiac function
HR, beats/min	81 ± 4	79 ± 3	0.319
CO, l/min	2.7 ± 0.3	2.7 ± 0.2	0.941
MAP, mmHg	111 ± 5	89 ± 2	< 0.001
LVEDP, mmHg	14 ± 1	23 ± 1	< 0.001
*Preload and afterload*
LVEDV, ml	40 ± 5	65 ± 3	0.002
Ea, mmHg/ml	4.4 ± 0.5	3.4 ± 0.2	0.05
*Systolic left ventricular function*
LVEF, %	64 ± 2	50 ± 2	< 0.001
LVESV, ml	19 ± 2	36 ± 2	< 0.001
dP/dt max, mmHg/s	3677 ± 368	2568 ± 105	< 0.001
Ees, mmHg/ml	6.1 ± 0.8	2.1 ± 0.2	< 0.001
V0, ml	-5 ± 2	-23 ± 9	0.113
*Ventricular-arterial coupling*
Ees/Ea	1.4 ± 0.2	0.6 ± 0.1	< 0.001
*Diastolic left ventricular function*
Active relaxation
Tau, ms	29 ± 5	36 ± 2	0.057
dP/dtmin, mmHg/s	-2821 ± 305	-1992 ± 72	0.007
Passive diastolic properties
β, 1/ml	0.053 ± 0.006	0.075 ± 0.011	0.191
Capacitance (15 mmHg), ml	55 ± 3	66 ± 5	0.177
Capacitance (20 mmHg), ml	61 ± 3	70 ± 6	0.249

Values are expressed as mean ± SEM. HR: heart rate; CO: cardiac output; MAP: mean arterial pressure; LV: left ventricular; ESV: end-systolic volume, EF: ejection fraction; Ees: end-systolic elastance; V0: volume intercept; Tau: time constant of relaxation; β, the chamber stiffness constant, is derived from the EDPVR equation (LVEDP = α e^βLVEDV); EDV: end-diastolic volume; EDP: end-diastolic pressure; Ea: arterial elastance.

ISSN: 1471-2261