Table 1 Total homocysteine concentrations, basal forearm blood flow (FBF) plus area under curve (AUC) for change in FBF following Placebo, oral Methionine and oral Methionine plus Vitamin C.

Vitamin C

Total

Homocysteine

Baseline

7.8 [6.1-9.5]

7.5 [6.0-9.0]

7.6 [6.2-9.0]

(μmol/L)

T = 4 hours

7.6 [6.3-8.9]

22.8 [19.8-25.8]^*

21.6 [18.3-24.9]^*

Basal FBF (ml 100 ml^-1 min^-1)

2.9 [1.9-3.8]

2.8 [1.5-4.0]

3.0 [1.9-4.1]

AUC endothelial-dependent

46.4 [41.3-51.4]

31.2 [20.5-41.9] †

31.4 [17.6-45.2] †

change in FBF (arbitrary units)

AUC endothelial-independent

22.0 [16.7-27.1]

22.2 [13.1-31.3.]

21.6 [18.3-24.9]

change in FBF (arbitrary units)

Mean difference in AUC from

-15.2 [-25.8 - -4.5]

-15 [-30-0]

placebo (endothelial-dependent)

Mean difference in AUC

Methionine vs. Vitamin C

0.2 [-18.5-18.9]

(endothelial-dependent)