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Table 1 Total homocysteine concentrations, basal forearm blood flow (FBF) plus area under curve (AUC) for change in FBF following Placebo, oral Methionine and oral Methionine plus Vitamin C.

From: The effect on endothelial function of vitamin C during methionine induced hyperhomocysteinaemia

   Placebo Methionine Methionine +
     Vitamin C
Total     
Homocysteine Baseline 7.8 [6.1-9.5] 7.5 [6.0-9.0] 7.6 [6.2-9.0]
(μmol/L)     
  T = 4 hours 7.6 [6.3-8.9] 22.8 [19.8-25.8]* 21.6 [18.3-24.9]*
Basal FBF (ml 100 ml-1 min-1) 2.9 [1.9-3.8] 2.8 [1.5-4.0] 3.0 [1.9-4.1]
AUC endothelial-dependent 46.4 [41.3-51.4] 31.2 [20.5-41.9] † 31.4 [17.6-45.2] †
change in FBF (arbitrary units)    
AUC endothelial-independent 22.0 [16.7-27.1] 22.2 [13.1-31.3.] 21.6 [18.3-24.9]
change in FBF (arbitrary units)    
Mean difference in AUC from   -15.2 [-25.8 - -4.5] -15 [-30-0]
placebo (endothelial-dependent)    
Mean difference in AUC    
Methionine vs. Vitamin C    0.2 [-18.5-18.9]
(endothelial-dependent)    
  1. Data are Mean plus [95% Confidence Intervals] p < 0.0001 vs. baseline & placebo, † p < 0.05 vs. placebo