From: The effect on endothelial function of vitamin C during methionine induced hyperhomocysteinaemia
 |  | Placebo | Methionine | Methionine + |
---|---|---|---|---|
 |  |  |  | Vitamin C |
Total | Â | Â | Â | Â |
Homocysteine | Baseline | 7.8 [6.1-9.5] | 7.5 [6.0-9.0] | 7.6 [6.2-9.0] |
(μmol/L) |  |  |  |  |
 | T = 4 hours | 7.6 [6.3-8.9] | 22.8 [19.8-25.8]* | 21.6 [18.3-24.9]* |
Basal FBF (ml 100 ml-1 min-1) | 2.9 [1.9-3.8] | 2.8 [1.5-4.0] | 3.0 [1.9-4.1] | |
AUC endothelial-dependent | 46.4 [41.3-51.4] | 31.2 [20.5-41.9] †| 31.4 [17.6-45.2] †| |
change in FBF (arbitrary units) | Â | Â | Â | |
AUC endothelial-independent | 22.0 [16.7-27.1] | 22.2 [13.1-31.3.] | 21.6 [18.3-24.9] | |
change in FBF (arbitrary units) | Â | Â | Â | |
Mean difference in AUC from | Â | -15.2 [-25.8 - -4.5] | -15 [-30-0] | |
placebo (endothelial-dependent) | Â | Â | Â | |
Mean difference in AUC | Â | Â | Â | |
Methionine vs. Vitamin C | Â | Â | 0.2 [-18.5-18.9] | |
(endothelial-dependent) | Â | Â | Â |