Inclusion criteria | Exclusion criteria |
---|---|
I. Informed consent for participation | I. Lacks capacity to consent for him or herself |
II. Severe aortic stenosis | |
  i. AVA <0.8 cm2 | II. Pre-existing neurological impairment |
  ii. Mean aortic valve gradient >40 mmHg |   i. Modified rankin score ≥ 3 (i.e. moderate disability; requiring some help, but able to walk without assistance) |
  iii. Peak jet velocity >4 m/s | |
III. Planned TAVI or SAVR | |
IV. High-surgical-risk | III. Contraindication to MRI (including incompatible metallic prosthesis/foreign body, inability to lie flat, claustrophobia requiring sedation) |
  i. STS score >8% | |
  ii. Logistic EuroSCORE >20% | |
  iii. Logistic EuroSCORE II >10% | IV. Non or poor English-speaking due to nature of and unknown validity in such populations cognitive testing |
V. Previous aortic valve repair/replacement | |
 | VI. Coronary artery disease requiring revascularisation (including patients undergoing combined AVR and CABG) |