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Table 5 Subgroups analysis for the associations of manganese with all-cause mortality

From: The relationship between serum manganese concentration with all-cause and cause-specific mortality: a retrospective and population-based cross-sectional study

 

Q1

Q2

Q3

Q4

P for trend

P for interaction

 

HR (95%CI)

HR (95%CI)

HR (95%CI)

HR (95%CI)

  

Age

     

0.164

 < 60

1.00

0.85 (0.51, 1.42)

0.83 (0.50, 1.40)

1.14 (0.67, 1.93)

0.756

 

 ≥ 60

1.00

1.15 (0.88, 1.51)

0.96 (0.72, 1.29)

1.18 (0.88, 1.58)

0.495

 

Sex

     

0.014

 Male

1.00

1.13 (0.84, 1.52)

1.00 (0.73, 1.37)

0.94 (0.65, 1.36)

0.762

 

 Female

1.00

0.93 (0.61, 1.40)

0.75 (0.48, 1.16)

1.43 (0.97, 2.09)

0.133

 

Race

     

0.001

 Mexican

1.00

1.28 (0.35, 4.73)

1.59 (0.48, 5.27)

1.83 (0.53, 6.35)

0.314

 

 American

      

  Other Hispanic

1.00

0.54 (0.12, 2.47)

0.74 (0.17, 3.20)

1.47 (0.32, 6.65)

0.508

 

  Non-Hispanic

1.00

0.86 (0.51, 1.45)

0.74 (0.41, 1.33)

0.85 (0.44, 1.63)

0.382

 

 Black

      

  Non-Hispanic

1.00

1.20 (0.88, 1.62)

1.02 (0.74, 1.41)

1.17 (0.84, 1.64)

0.525

 

 White

      

  Other race

1.00

12.81 (0.96, 170.55)

3.33 (0.22, 50.65)

12.26 (0.88, 170.84)

0.187

 

Hypertension

     

0.092

 No

1.00

0.95 (0.58, 1.55)

0.94 (0.56, 1.57)

1.11 (0.64, 1.91)

0.804

 

 Yes

1.00

1.17 (0.89, 1.54)

0.99 (0.74, 1.33)

1.33 (0.99, 1.79)

0.161

 

DM

     

0.218

 No

1.00

1.22 (0.90, 1.65)

0.93 (0.67, 1.31)

1.35 (0.97, 1.87)

0.243

 

 Yes

1.00

0.96 (0.64, 1.43)

0.96 (0.65, 1.42)

1.09 (0.71, 1.67)

0.794

 

CHD

     

0.162

 No

1.00

1.01 (0.78, 1.31)

0.94 (0.71, 1.23)

1.21 (0.92, 1.60)

0.323

 

 Yes

1.00

2.14 (1.04, 4.40) *

1.40 (0.68, 2.90)

1.69 (0.78, 3.68)

0.271

 

CHF

     

0.007

 No

1.00

1.03 (0.80, 1.34)

0.84 (0.63, 1.11)

1.24 (0.95, 1.63)

0.423

 

 Yes

1.00

1.95 (0.91, 4.18)

2.09 (1.01, 4.33)*

1.12 (0.48, 2.62)

0.437

 

Angina pectoris

     

0.163

 No

1.00

1.07 (0.84, 1.37)

0.96 (0.74, 1.25)

1.20 (0.92,1.56)

0.350

 

 Yes

1.00

1.04 (0.27, 4.06)

0.55 (0.13, 2.26)

2.13 (0.61, 7.48)

0.412

 

Heart attack

     

0.033

 No

1.00

1.01 (0.78, 1.30)

0.88 (0.67, 1.16)

1.19 (0.91, 1.57)

0.482

 

 Yes

1.00

2.41 (1.13, 5.16) *

2.45 (1.05, 5.71)

2.10 (0.88, 5.03)

0.071

 

Stroke

     

0.153

 No

1.00

1.04 (0.81, 1.34)

0.98 (0.75, 1.27)

1.21 (0.92, 1.59)

0.315

 

 Yes

1.00

1.57 (0.86, 2.88)

0.50 (0.25, 1.03)

1.66 (0.92, 2.97)

0.656

 

BMI

     

0.134

 < 30 kg m2

1.00

1.01 (0.74, 1.37)

1.02 (0.75, 1.40)

1.28 (0.93, 1.78)

0.194

 

 ≥ 30 kg/m2

1.00

1.18 (0.81, 1.72)

0.82 (0.53, 1.27)

1.18 (0.77, 1.80)

0.865

 
  1. Analysis was adjusted for age, sex, race/ethnicity. education level, marital status, family poverty-income ratio, smoker, alcohol user, hypertension, diabetes mellitus, chronic heart disease, chronic heart failure, angina, heart attack, stroke, systolic blood pressure, diastolic blood pressure, body mass index, waist circumference, physical activity, mean energy intake, hemoglobin, glucose, blood urea nitrogen, uric acid, serum creatinine, high density lipoprotein-cholesterol, total cholesterol, and triglycerides
  2. Abbreviations: Q1 1.570–7.415 ug/L, Q2 7.416–9.230 ug/L, Q3 9.231–11.555 ug/L, Q4 11.556–57.770 ug/L, *P < 0.05, DM diabetes mellitus, BMI body mass index, HR hazard ratio, CI confidence interval