Overcoming barriers for left atrial appendage thrombus: a systematic review of left atrial appendage closure

Table 3 Follow-up and clinical outcomes

Study	Follow-Up	Adverse Clinical Outcomes	Reference
Bordignon 2019	4.6 mos	1 major bleeding	[12]
Jin 2022	12.8 mos	1 DRT, 3 PDL	[13]
Marroquin 2022	18 mos	1PDL, 1 major bleeding	[19]
Beneduce 2019	1 mo	N/A	[20]
Lange 2016	1.5 mos	N/A	[21]
Saccà 2017	until discharge	N/A	[22]
Jalal 2016	8.6 ± 2 mos	1PDL	[23]
Lee 2018	27.1 ± 20.3 mos	1 stroke, 1 DRT, 2 PDL	[24]
Popescu 2022	3 mos	N/A	[25]
Tan 2021	3.75 mos	1 major bleeding	[26]
Tsai 2023	20.4 mos	N/A	[27]
Bellmann 2017	3 mos	N/A	[28]
Aytemir 2016	48 h	N/A	[29]
Dugo 2016	1.5 mos	N/A	[30]
Lee 2017	4 d	N/A	[31]
De Roeck 2019	9 mos	N/A	[32]
Chang 2023	5 mos	N/A	[33]
Mohandes 2020	until discharge	N/A	[34]
Kaczmarek 2021	10 mos	1 DRT, 1 PDL, 1 death	[35]
Marcon 2023	6 mos	N/A	[36]
Cruz-Gonzalez 2017	until discharge	N/A	[37]
Cammalleri 2016	until discharge	N/A	[38]
Pak 2013	1.5 mos	N/A	[39]
Yadav 2017	1.5 mos	N/A	[40]
Martins 2018	1 mo	N/A	[41]
Del Furia 2017	until discharge	N/A	[42]

DRT device-related thrombus, PDL peri-device leakage
N/A indicates data not available. Adverse clinical outcomes included a composite of death, stroke or other systemic thromboembolism, DRT, major bleeding, PDL, transient ischemic attack and device-related complications during follow-up. Major bleeding was defined as gastrointestinal bleeding, cerebral hemorrhage, intramuscular bleeding, etc.

ISSN: 1471-2261