Table 2 Distribution frequencies of APOE genotype and allele in patients and controls
Variable | Genotype/allele | Total (n = 1160) | Controls (n = 351) | T2DM patients (n = 431) | T2DM + CAD patients (n = 378) | χ2 | p values |
|---|---|---|---|---|---|---|---|
APOE genotype | Â | Â | Â | Â | Â | Â | Â |
|  | ɛ2/ɛ2 | 6(0.5%) | 2(0.6%) | 1(0.2%) | 3(0.8%) | 1.261 | 0.525 |
|  | ɛ2/ɛ3 | 151(13.0%) | 48(13.7%) | 55(12.8%) | 48(12.7%) | 0.193 | 0.904 |
|  | ɛ2/ɛ4 | 28(2.4%) | 8(2.3%) | 8(1.9%) | 12(3.2%) | 1.525 | 0.471 |
|  | ɛ3/ɛ3 | 800(69.0%) | 255(72.6%) | 318(73.8%) | 227(60.1%) | 20.926 | < 0.001 |
|  | ɛ3/ɛ4 | 162(14.0%) | 34(9.7%) | 45(10.4%) | 83(22.0%) | 29.900 | < 0.001 |
|  | ɛ4/ɛ4 | 13(1.1%) | 4(1.1%) | 4(0.9%) | 5(1.3%) | 0.285 | 0.939 |
APOE allele | Â | Â | Â | Â | Â | Â | Â |
|  | ε2 | 191(8.2%) | 60(8.5%) | 65(7.5%) | 66(8.7%) | 0.886 | 0.647 |
|  | ε3 | 1913(82.5%) | 592(84.3%) | 736(85.4%) | 585(77.4%) | 20.271 | < 0.001 |
|  | ε4 | 216(9.3%) | 50(7.1%) | 61(7.1%) | 105(13.9%) | 27.843 | < 0.001 |
|  | HWE (χ2, P) | χ2 = 9.060, p = 0.060 | χ2 = 7.970, p = 0.093 | χ2 = 5.957, p = 0.202 | χ2 = 1.825, p = 0.768 |  |  |