Causal association between helicobacter pylori and atherosclerosis: a two-sample Mendelian randomization

Table 1 The result of heterogeneity test and pleiotropy test of MR analysis

exposures	outcomes	nSNPs	Heterogeneity test			Pleiotropy test	F
exposures	outcomes	nSNPs	method	Q	P	Pleiotropy test	F
Anti-H.pylori IgG	Other AS	10	MR-Egger IVW	8 9	0.05 0.06	0.54	22.92
	Cereb.AS	8	MR-Egger IVW	6 7	0.90 0.91	0.50	22.98
	Coron.AS	10	MR-Egger IVW	8 9	0.25 0.25	0.37	22.92
	PAD	10	MR-Egger IVW	8 9	0.31 0.24	0.20	22.92
CagA	Other AS	10	MR-Egger IVW	8 9	0.05 0.06	0.54	22.49
	Cereb.AS	10	MR-Egger IVW	8 9	0.46 0.53	0.58	22.49
	Coron.AS	10	MR-Egger IVW	8 9	0.70 0.78	0.83	22.49
	PAD	10	MR-Egger IVW	8 9	0.13 0.18	0.80	22.49
Catalase	Other As	8	MR-Egger IVW	6 7	0.18 0.22	0.54	22.91
	Cereb.AS	8	MR-Egger IVW	6 7	0.74 0.71	0.34	22.91
	Coron.AS	8	MR-Egger IVW	6 7	0.70 0.79	0.84	22.91
	PAD	8	MR-Egger IVW	6 7	0.42 0.53	0.84	22.91
OMP	Other AS	4	MR-Egger IVW	2 3	0.82 0.73	0.44	22.32
	Cereb.AS	9	MR-Egger IVW	6 7	0.90 0.91	0.50	24.40
	Coron.AS	8	MR-Egger IVW	4 5	0.25 0.25	0.37	24.20
	PAD	6	MR-Egger IVW	4 5	0.47 0.27	0.17	23.23
VacA	Other AS	14	MR-Egger IVW	12 13	0.93 0.89	0.25	23.19
	Cereb.AS	14	MR-Egger IVW	12 13	0.81 0.79	0.32	23.19
	Coron.AS	12	MR-Egger IVW	9 10	0.70 0.73	0.44	22.87
	PAD	13	MR-Egger IVW	12 13	0.81 0.85	0.64	23.13

Anti-H.pylori IgG Anti-H. pylori IgG levels, CagA H. pylori CagA antibody levels, Catalase H. pylori Catalase antibody levels, OMP H. pylori OMP antibody levels, VacA H. pylori VacA antibody levels, Other AS Atherosclerosis, excluding cerebral, coronary and PAD, Cereb.AS Cerebral atherosclerosis, Coron.AS Coronary atherosclerosis, PAD Peripheral atherosclerosis

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