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Table 3 Univariable and multivariable Cox regression models (stepwise selection) in the diabetes group for the primary outcome of all-cause mortality or heart failure hospitalisation

From: Global longitudinal strain and plasma biomarkers for prognosis in heart failure complicated by diabetes: a prospective observational study

 

Univariable Model

Multivariable Model

(n = 158)

HR (95% CI)

P Value

HR (95% CI)

p Value

Clinical

    

Age (per 10-year increment)

1.21

(0.90–1.60)

0.202

  

Male sex

0.85

(0.41–1.75)

0.665

  

Body mass index

0.99

(0.94–1.05)

0.827

  

Hypertension

0.94

(0.50–1.76)

0.838

  

Diabetes Type

0.88

(0.28–2.84)

0.836

  

Smoking

0.80

(0.46–1.40)

0.436

  

Coronary artery disease

1.41

(0.72–2.75)

0.314

  

NYHA Functional Class

1.34

(0.86–2.08)

0.200

  

Systolic blood pressure (per 10mmHg increment)

0.86

(0.75–0.98)

0.028

§

 

Plasma Biomarkers

    

NT-proBNP (per 100pg/mL increment)

1.01

(1.00-1.02)

0.007

§

 

hs-TnT (per 1ng/L increment)

1.01

(1.00-1.02)

0.016

§

 

GDF-15 (per 100pg/mL increment)

1.02

(1.01–1.03)

0.003

§

 

sST2 (per 1ng/mL increment)

1.03

(1.01–1.06)

0.003

1.03

(1.00-1.06)

0.02

Gal-3 (per 1ng/mL increment)

1.06

(1.00-1.12)

0.061

 §

 

CMR Markers

    

LVEDVi (per 10mL/m2 increment)

1.07

(0.99–1.15)

0.076

 §

 

LVMi (per 10 g/m2 increment)

1.01

(0.88–1.15)

0.928

  

LV ejection fraction (per 5% increment)

0.89

(0.81–0.99)

0.031

§

 

GLS (per 1% increment)

1.15

(1.06–1.25)

0.001

1.12

(1.03–1.21)

0.01

Presence of LGE

1.42

(0.69–2.92)

0.342

  

Native T1 (per 10ms increment)

1.07

(1.00-1.14)

0.04

§

 

ECV (per 1% increment)

1.06

(0.98–1.15)

0.139

  
  1. Abbreviations:; NYHA: New York Heart Association; NT-proBNP: N-terminal pro-brain natriuretic peptide; hs-TnT: high-sensitivity troponin T; GDF-15: growth differentiation factor 15; sST2: soluble ST2; Gal-3: galectin 3; LVEDVi: Left ventricular end-diastolic volume indexed to body surface area; LVMi: Left ventricular mass index; GLS: Global longitudinal strain; LGE: Late gadolinium enhancement; ECV: Extracellular volume. § Assessed for inclusion in multivariable model but not retained