Table 1 General characteristics of study participants
From: APOE ε4 carriage associates with improved myocardial performance from adolescence to older age
NSHD | SABRE | UK Biobank | ALSPAC | ||
|---|---|---|---|---|---|
Variable | Count (%), n = 1467 | Count (%), n = 1187 | Cohort (%), n = 32,972 | Cohort (%), n = 1397 | |
Exposure: APOE ε4 genotype | ε2ε2 | 8 (0.55%) | 6 (0.51%) | 178 (0.54%) | 12 (0.86%) |
ε2ε3 | 169 (11.54%) | 130 (11.95%) | 4046 (12.27%) | 200 (14.32%) | |
ε2ε4 | 44 (3.00%) | 27 (2.28%) | 773 (2.34%) | 35 (2.50%) | |
ε3ε3 | 855 (57.36%) | 726 (61.16%) | 19,587 (59.41%) | 801 (57.34%) | |
ε3ε4 | 343 (23.41%) | 269 (22.66%) | 7647 (23.19%) | 322 (23.05%) | |
ε4ε4 | 46 (3.14%) | 29 (2.44%) | 741 (2.25%) | 27 (1.93%) | |
Echo at 60–64 years | APOE ε4 status | Median (IQR) | Median (IQR) | Median (IQR) | Median (IQR) |
EF | −/− | 65.06 (60.02, 69.27) | 62.17 (55.81, 68.51) | 59.75 (55.84, 63.69) | 65.77 (61.67, 69.29) |
+/− | 64.73 (59.33, 69.43) | 63.05 (57.66, 69.74) | 59.64 (55.85, 63/66) | 65.61 (60.90, 69.47) | |
+/+ | 66.68 (61.94, 69.34) | 62.07 (56.71, 67.73) | 60.10 (56.37, 63.95) | 65.26 (62.57, 67.21) | |
E/e’ | −/− | 7.72 (6.51, 9.20) | 8.12 (7.11, 10.78) | N/A | 5.42 (4.69, 6.20) |
+/− | 7.52 (6.30, 8.87) | 8.91 (7.51, 10.53) | N/A | 5.43 (4.71, 6.19) | |
+/+ | 7.18 (6.07, 8.37) | 8.35 (6.73, 9.86) | N/A | 5.16 (4.47, 5.55) | |
LPDSR | −/− | N/A | N/A | 1.59 (1.23, 2.00) | N/A |
+/− | N/A | N/A | 1.61 (1.25, 2.01) | N/A | |
+/+ | N/A | N/A | 1.62 (1.27, 2.00) | N/A | |
RPDSR | −/− | N/A | N/A | −5.70 (−7.03, −4.38) | N/A |
+/− | N/A | N/A | −5.77 (−7.05, −4.43) | N/A | |
+/+ | N/A | N/A | −5.71 (−7.05, − 4.43) | N/A | |
LVmass | −/− | 108.89 (92.86, 131.80) | 93.38 (79.59, 107.72) | 82.71 (68.41, 100.79) | 123.90 (105.44, 150.22) |
+/− | 108.38 (87.62, 137.70) | 93.75 (80.83, 109.64) | 82.53 (68.51, 100.49) | 123.4 (102.7, 148.7) | |
+/+ | 113.25 (98.08, 127.13) | 91.24 (80.83, 109.2) | 81.69 (68.78, 100.88) | 132.65 (015.95, 162.72) | |
MCF | −/− | 0.47 (0.37, 0.59) | 0.58 (0.49, 0.70) | 1.07 (0.95, 1.21) | 0.45 (0.39, 0.51) |
+/− | 0.51 (0.39, 0.65) | 0.60 (0.50, 0.71) | 1.08 (0.95, 1.22) | 0.46 (0.40,0.52) | |
+/+ | 0.53 (0.42, 0.60) | 0.62 (0.55, 0.68) | 1.09 (0.97, 1.23) | 0.45 (0.38, 0.50) | |
LVPWTs | −/− | 1.57 (1.40, 1.74) | 1.48 (1.35, 1.62) | N/A | 1.32 (1.23, 1.44) |
+/− | 1.58 (1.42, 1.80) | 1.45 (1.32, 1.59) | N/A | 1.32 (1.22, 1.43) | |
+/+ | 1.60 (1.47, 1.74) | 1.39 (1.26, 1.60) | N/A | 1.33 (1.24, 1.48) | |
LVPWTd | −/− | 0.98 (0.87, 1.09) | 1.02 (0.92, 1.13) | 5.65 (5.14, 6.21) | 0.86 (0.79, 0.95) |
+/− | 0.98 (0.88, 1.10) | 1.01 (0.91, 1.12) | 5.64 (5.15, 6.23) | 0.85 (0.78, 0.93) | |
+/+ | 0.96 (0.87, 1.04) | 0.98 (0.90, 1.10) | 5.67 (5.17, 6.26) | 0.85 (0.78, 0.94) | |
IVSs | −/− | 1.50 (1.34, 1.68) | 1.58 (1.42, 1.74) | N/A | 1.17 (1.07, 1.30) |
+/− | 1.51 (1.35, 1.69) | 1.57 (1.40, 1.76) | N/A | 1.17 (1.07, 1.28) | |
+/+ | 1.50 (1.36, 1.64) | 1.51 (1.44, 1.70) | N/A | 1.15 (1.04, 1.29) | |
IVSd | −/− | 1.04 (0.91, 1.18) | 1.15 (1.03, 1.30) | 5.59 (4.98, 6.13) | 0.83 (0.75, 0.92) |
+/− | 1.04 (0.90, 1.18) | 1.14 (1.01, 1.29) | 5.58 (4.98, 6.12) | 0.82 (0.74, 0.90) | |
+/+ | 1.09 (0.93, 1.15) | 1.09 (1.04, 1.21) | 5.58 (4.97, 6.12) | 0.84 (0.76, 0.92) | |
Covariates | Count (%) or Median (IQR) | Count (%) or Median (IQR) | Count (%) or Median (IQR) | Count (%) or Median (IQR) | |
Age | 62 (0) | 52.08 (7.27) | 63.63 (7.57) | 20.5 (0) | |
Sex, male | 708 (48.32%) | 911 (76.75%) | 15,750 (47.77%) | 581 (41.59%) | |
BMI | 26.94 (24.49, 30.22) | 27.00 (24.35, 29.90) | 25.84 (23.46, 28.77) | 22.96 (20.73, 25.60) | |
CVD, Yes | 875 (8.72%) | 232 (19.55%) | 2153 (6.53%) | 0 (0%) | |
Diabetes, Yes | 321 (21.88%) | 256 (21.57%) | 1991 (6.04%) | 8 (0.57%) | |
High cholesterol, Yes | 282 (19.22%) | 235 (19.80%) | 6145 (18.64%) | 60 (5.16%) | |
Hypertension | 719 (50.65%) | 700 (58.98%) | 9106 (27.62%) | 64 (5.72%) | |