Fig. 2
From: APOE ε4 carriage associates with improved myocardial performance from adolescence to older age
Graphical abstract. Combining data from four British cohorts–1946 National Survey of Health and Development (NSHD), Southall and Brent Revised (SABRE), UK Biobank and Avalon Longitudinal Study of Parents and Children (ALSPAC)–we explored whether APOE ε4 carriage associates with beneficial or unfavorable left ventricular (LV) structural and functional parameters by echocardiography and cardiovascular magnetic resonance (CMR). Based on the presence of APOE ε4, genotypes were divided into: APOE ε4 (ε2ε4, ε3ε4, ε4ε4) and non-APOE ε4 carriers. Compared to the non-APOE ε4 group, APOE ε4 carriers had a higher myocardial contraction fraction resulting in greater LV stroke volume generation per 1 mL of myocardium and better longitudinal strain rates compared to non APOE ε4 carriers