Table 10 Survival analysis for 30-day HF rehospitalization using categorical covariates
30-day heart failure rehospitalization | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Factor | Threshold | Univariate analysis | Multivariate analysis | ||||||||
Cause-specific hazards | Schoenfeld residuals | Subdistribution hazards | Cause-specific hazards | Schoenfeld residuals | Subdistribution hazards | ||||||
HR (95%CI) | p-value | p-value | HR (95%CI) | p-value | HR (95%CI) | p-value | p-value | HR (95%CI) | p-value | ||
Admission | |||||||||||
 Grading orthoedema score |  |  | 0.89 | 0.13 |  | 0.82 |  |  |  |  |  |
  No congestion | 0 | 1.00 (reference) |  |  |  |  | 1.00 (reference) |  |  |  |  |
  Low grade | 1–2 | 1.15 (0.14–9.17) | 0.90 |  | 1.12 (0.15–8.08) | 0.91 |  |  |  |  |  |
  High grade | 3–4 | 0.86 (0.1–7.65) | 0.89 |  | 0.77 (0.1–6.15) | 0.80 |  |  |  |  |  |
 NT-proBNP | > 4577.00 pg/mL | 0.76 (0.25–2.26) | 0.62 | 0.31 | 0.69 (0.23–2.01) | 0.50 | 1.53 (0.38–6.14) | 0.55 | 0.35 | 1.28 (0.26–6.28) | 0.76 |
 hsTnT | > 38.53 pg/mL | 0.24 (0.07–0.88) | 0.02 | 0.12 | 0.23 (0.07–0.82) | 0.01 | 0.18 (0.04–0.87) | 0.03 | 0.17 | 0.2 (0.03–1.22) | 0.08 |
 GDF-15 | > 6221.50 pg/mL | 1.4 (0.44–4.4) | 0.56 | 0.34 | 1.26 (0.41–3.89) | 0.69 | 1.76 (0.54–5.70) | 0.35 | 0.38 | 1.62 (0.46–5.67) | 0.45 |
Discharge | |||||||||||
 Grading orthoedema score | ≥ 1 (congestion present) | 2.92 (0.96–8.93) | 0.08 | 0.65 | 2.92 (0.99–8.63) | 0.08 |  |  |  |  |  |
 NT-proBNP | > 4577.00 pg/mL | 1.71 (0.52–5.62) | 0.37 | 1.00 | 1.71 (0.53–5.52) | 0.37 | 3.99 (0.96–16.6) | 0.06 | 0.64 | 3.99 (1.02–15.7) | 0.047 |
 hsTnT | > 38.53 pg/mL | 0.4 (0.11–1.51) | 0.15 | 0.53 | 0.4 (0.11–1.47) | 0.15 | 0.1 (0.02–0.47) | < 0.01 | 0.80 | 0.1 (0.02–0.48) | < 0.01 |
 GDF-15 | > 6221.50 pg/mL | 6.3 (1.36–29.2) | < 0.01 | 0.49 | 6.3 (1.4–28.31) | < 0.01 | 8.22 (1.70–39.7) | < 0.01 | 0.64 | 8.24 (1.68–40.4) | < 0.01 |
 NT-proBNP admission:discharge | > 1.0992464 | 0.2 (0.04–0.95) | 0.02 | 0.64 | 0.2 (0.05–0.92) | 0.02 | 0.1 (0.01–0.81) | 0.03 | 0.40 | 0.1 (0.01–0.78) | 0.03 |
 hsTnT admission:discharge | > 1.13408464 | 0.84 (0.26–2.74) | 0.77 | 0.66 | 0.84 (0.26–2.7) | 0.77 | 0.99 (0.28–3.44) | 0.98 | 0.77 | 0.99 (0.29–3.37) | 0.98 |
 GDF-15 admission:discharge | > 1.8079528 | 0.41 (0.11–1.6) | 0.18 | 0.36 | 0.41 (0.11–1.59) | 0.18 | 0.4 (0.10–1.58) | 0.19 | 0.34 | 0.4 (0.10–1.57) | 0.19 |