Table 3 Unadjusted and age-adjusted association of current allopurinol use with Incident acute cardiovascular event composite (MI or stroke) among patients with diabetes and gout

 Current

0.71 (0.56, 0.89)

0.003

0.67 (0.53, 0.85)

0.0007

 Previous

Ref

Ref

Male Gender

0.85 (0.68, 1.06)

0.14

1.01 (0.80, 1.27)

0.95

  ≤ 50

0.40 (0.17, 0.92)

0.03

-

-

 51-60

0.86 (0.49, 1.50)

0.59

-

-

 66-70

0.88 (0.54, 1.45)

0.62

-

-

 71-75

1.64 (1.03, 2.61)

0.04

-

-

 76-80

1.58 (0.97, 2.59)

0.07

-

-

  > 80

2.70 (1.70, 4.30)

<0.0001

-

-

 61-65

Ref

-

-

 Asian

1.05 (0.62, 1.78)

0.85

0.95 (0.56, 1.60)

0.84

 Black

0.90 (0.67, 1.21)

0.50

1.03 (0.77, 1.39)

0.84

 Hispanic

1.35 (0.73, 2.47)

0.34

1.54 (0.84, 2.82)

0.16

 Other

1.53 (0.79, 2.98)

0.21

1.59 (0.82, 3.10)

0.17

 Missing

0.58 (0.30, 1.13)

0.11

0.73 (0.37, 1.43)

0.36

 White

Ref

Ref

 Hypertension

1.08 (0.78, 1.50)

0.63

1.01 (0.73, 1.41)

0.93

 Hyperlipidemia

0.90 (0.69, 1.17)

0.43

0.91 (0.69, 1.19)

0.49

 COPD

1.10 (0.76, 1.59)

0.63

1.09 (0.75, 1.58)

0.66

 Renal disease

1.40 (1.11, 1.78)

0.005

1.34 (1.06, 1.70)

0.02

 Peripheral vascular disease

1.08 (0.73, 1.60)

0.70

0.96 (0.65, 1.43)

0.86

 Immune diseases

1.05 (0.80, 1.39)

0.71

1.07 (0.81, 1.41)

0.62

Colchicine use

0.74 (0.51, 1.09)

0.13

0.77 (0.53, 1.12)

0.18