Table 2 Genotype and allele frequencies of thrombotic gene variants in the study population

FV: Leiden

Normal

32 (94.1)

20 (87.0)

0.384

1.0

1.0

1691G > A

Hetero

2 (5.9)

3 (13.0)

2.4 (0.3–15.6)

3.08 (0.3–26.3)

p HWE

0.859

0.737

MAF (A)

0.03

0.07

0.359

0.4 (0.05–3.1)

FV: R2

Normal

30 (8 8.2)

14 (60.9)

0.024

1.0

1.0

H1299R

Hetero

4 (11.8)

9 (39.1)

4.8 (1.2–18.3)

7.1 (1.49–33.6)

4070A > G

p HWE

0.715

0.243

MAF (G)

0.06

0.20

0.024

3.8 (1.12–13.5)

FII: PTH

Normal

34 (100)

23 (100)

NA

NA

20210G > A

p HWE

NA

NA

FXIII

Normal

30 (88.2)

17 (73.9)

0.287

1.0

1.0

V34L

Hetero

4 (11.8)

6 (26.1)

2.6 (0.6–10.7)

2.29 (0.48–1.5)

p HWE

0.715

0.471

MAF (T)

0.06

0.13

0.185

0.4 (0.09–1.6)

MTHFR

Normal

22 (64.7)

12 (52.2)

0.017

1.0

1.0

677C > T

Hetero

12 (35.3)

6 (26.1)

0.9 (0.2–3.1)

0.82 (0.21–3.3)

Homo

0 (0.0)

5 (21.7)

19 (1.0–388)

Dominant model

12 (35.3)

11 (47.8)

1.6 (0.5–4.9)

p HWE

0.211

0.041

MAF (T)

0.18

0.35

0.037

2.4 (1.04–5.9)

MTHFR

Normal

10 (29.4)

8 (34.8)

0.648

1.0

1.0

1298A > C

Hetero

16 (47.1)

8 (34.8)

0.6 (0.1–2.2)

0.87 (0.21–3.6)

Homo

8 (23.5)

7 (30.4)

1.1 (0.2–4.3)

1.46 (0.33–6.4)

Dominant model

24 (70.6)

15 (65.2)

0.7 (0.2–2.4)

p HWE

0.745

0.146

MAF (C)

0.47

0.48

0.935

0.9 (0.4–2.1)

PAI-1

4G/4G

10 (29.4)

7 (30.4)

0.698

1.0

1.0

4G/5G

4G/5G

18 (52.9)

10 (43.5)

0.7 (0.2–2.7)

1.15 (0.24–5.3)

5G/5G

6 (17.6)

6 (26.1)

1.4 (0.3–6.3)

1.36 (0.27–6.8)

Dominant model

24 (70.5)

16 (69.6)

0.9 (0.3–3.0)

p HWE

0.667

0.536

MAF (5G)

0.44

0.48

0.696

0.8 (0.4–1.8)