Mercury exposure and risk of cardiovascular disease: a nested case-control study in the PREDIMED (PREvention with MEDiterranean Diet) study

Table 4 Relative risk of cardiovascular disease, according to increases in fish/seafood consumption from baseline to third year of follow-up and baseline toenail mercury, among case participants and matched controls in the PREDIMED trial

	Increase in Fish/seafood consumption & baseline toenail Mercury
	Low Hg/No increase in fish	Low Hg/Increased Fish	High Hg/No increase in fish	High Hg/Increased Fish
Mean mercury (μg/g)	0.33 (0.11)	0.33 (0.10)	0.99 (0.59)	0.84 (0.26)
% with high fish in MeDiet score	52	100	67	100
Total sample
Cases/matched controls	62/87	16/38	54/116	14/30
Matched OR^a (95% CI)	1 (ref.)	0.46 (0.21, 1.01)	0.62 (0.38, 1.03)	0.48 (0.20, 1.15)
Matched OR^b (95% CI)	1 (ref.)	0.52 (0.23, 1.17)	0.65 (0.38, 1.12)	0.52 (0.20–1.34)
Matched OR^c (95% CI)	1 (ref.)	0.50 (0.21, 1.18)	0.66 (0.37, 1.16)	0.54 (0.20, 1.44)

^aModels are from conditional logistic regression analyses with matching factors sex and age and adjusted for PREDIMED center
^bAdditionally djusted for month of toenail collection, smoking, hypertension, hypercholestaerolemia, diabetes and family history of premature coronary heart disease
^cAdditionally adjusted for intervention group, total energy intake, body mass index, physical activity (quartiles), alcohol intake (<5/10 gr, moderate consumption, >25/50 g in women/men) and non-fish consumption of n-3 fatty acids (continuous g/d)

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