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Table 3 Clinical outcomes

From: High platelet reactivity affects the clinical outcomes of patients undergoing percutaneous coronary intervention

 

NPR on aspirin (n = 1240)

HPR on aspirin (n = 91)

P value

NPR on clopidogrel (n = 891)

HPR on clopidogrel (n = 437)

P value

In hospital

 Definite/probable Stent thrombosis

1

0

NS

0

1

0.329

 All cause death

0

0

NS

0

0

NS

 Cardiac death

0

0

NS

0

0

NS

 Spontaneous MI

2

0

NS

0

2

0.108

 TLR

1

0

NS

0

1

0.329

 TVR

1

0

NS

0

1

0.329

 Ischemic stroke

8 (0.6)

0

NS

4 (0.4)

4 (0.9)

0.451

 All bleeding

39 (3.1)

3 (3.3)

0.762

30 (3.4)

12 (2.7)

0.619

 Hemorrhagic stroke

3 (0.2)

0

NS

3 (0.3)

0

0.555

 MACCE

10 (0.8)

0

NS

4 (0.5)

6 (1.4)

0.090

At 1 years

 Definite/probable Stent thrombosis

3 (0.2)

8 (8.8)

< 0.001

1 (0.1)

10 (2.3)

< 0.001

 All cause death

8 (0.6)

2 (2.2)

0.146

3 (0.3)

7 (1.6)

0.018

 Cardiac death

2 (0.2)

2 (2.2)

0.025

1 (0.1)

3 (0.7)

0.107

 Spontaneous MI

17 (1.4)

3 (3.3)

0.152

10 (1.1)

10 (2.3)

0.147

 TLR

30 (2.4)

0 (0)

0.260

25 (2.8)

5 (1.1)

0.075

 TVR

31 (2.5)

0 (0)

0.265

25 (2.8)

6 (1.4)

0.123

 Ischemic stroke

9 (0.7)

1 (1.1)

0.509

9 (1.0)

1 (0.2)

0.180

 All bleeding

64 (5.2)

3 (3.3)

0.619

48 (5.4)

19 (4.3)

0.505

 Hemorrhagic stroke

5 (0.4)

0

NS

3 (0.3)

2 (0.5)

0.666

 MACCE

40 (3.2)

5 (5.5)

0.228

30 (3.4)

15 (3.4)

0.951

At 2 years

 Definite/probable Stent thrombosis

5 (0.4)

9 (9.9)

< 0.001

1 (0.1)

13 (3.0)

< 0.001

 All cause death

20 (1.6)

7 (7.7)

0.002

3 (0.3)

23 (5.3)

< 0.001

 Cardiac death

4 (0.3)

7 (7.7)

< 0.001

1 (0.1)

10 (2.3)

< 0.001

 Spontaneous MI

23 (1.9)

9 (9.9)

< 0.001

11 (1.2)

21 (4.8)

< 0.001

 TLR

60 (4.8)

5 (5.5)

0.799

51 (5.7)

14 (3.2)

0.057

 TVR

65 (5.2)

5 (5.5)

0.809

51 (5.7)

19 (4.3)

0.360

 Ischemic stroke

16 (1.3)

2 (2.2)

0.352

12 (1.3)

6 (1.4)

NS

 All bleeding

118 (10.0)

8 (9.2)

NS

93 (10.9)

33 (7.9)

0.110

 Hemorrhagic stroke

8 (0.6)

0 (0)

NS

4 (0.4)

4 (0.9)

0.451

 MACCE

106 (8.5)

15 (16.5)

0.021

66 (7.4)

54 (12.4)

0.004

  1. MI myocardial infarction, TLR target lesion revascularization, TVR target vessel revascularization, MACCE adverse cardiovascular and cerebrovascular events, NPR normal platelet reactivity, HPR high platelet reactivity