Inclusion criteria | |
(1) Age ≥18 years | |
(2) Patients scheduled to undergo clinically-indicated non-emergent invasive coronary angiography | |
Exclusion criteria | |
(1) Known coronary artery disease (myocardial infarction, percutaneous coronary interventions, coronary artery bypass graft) | |
(2) Hemodynamic instability | |
(3) Inability to provide written informed consent | |
(4) Concomitant participation in another clinical trial in which an individual is subject to investigational drug or device | |
(5) Pregnancy or unknown pregnancy status | |
(6) Absolute contraindication to iodinated contrast due to prior near-fatal anaphylactoid reaction (laryngospasm, bronchospasm, cardiorespiratory collapse, or equivalent) | |
(7) Impaired chronic renal function (serum creatinine ≥1.7 mg/dl or Glomerular Filtration Rate <30 ml/min) | |
(8) Baseline irregular heart rhythm (e.g., atrial fibrillation, etc.) | |
(9) Heart rate ≥100 beats per minute | |
(10) Systolic blood pressure ≤90 mm Hg | |
(11) Contraindications to β blockers or nitroglycerin or adenosine |