Author, year | Different regimens of anti-aggregation/anticoagulation used |
---|---|
ADMIT [28] | Oral aspirin 300 mg as a loading dose (or only 100 mg if the patient was on aspirin therapy) continued by 100 mg/day indefinitely, 600 mg clopidogrel loading dose continued by 75 mg/day for one year and IV 60 mg/ kg unfractionated heparin as loading dose to keep activating clotting time during procedure > 250 second. |
Bulum 2012 [29] | 300Â mg of aspirin and 600Â mg of clopidogrel and a weight-adjusted dose of unfractionated heparin; the usage of glycoprotein IIb/IIIa inhibitor (eptifibatide) was left to the discretion of the operator. |
Chao 2008 [30] | Aspirin 300 mg and clopidogrel 300 mg were given as loading dose, with intravenous heparin 70– 100 U/kg to achieve activated clotting time (ACT) > 200 s prior to intervention. |
De Luca 2006 [31] | Aspirin 300Â mg orally and heparin 8000Â IU intravenously before the procedure and abciximab as a 0.25Â mg/kg bolus and 0.125Â mg/kg/min intravenous infusion immediately before the revascularisation and continued for 12Â hours. |
Aspirin 300Â mg, intravenous heparin, abciximab at a standard dose, and clopidogrel 300Â mg before the revascularization. | |
EXPORT [34] | The choice of medication during the procedure such as aspirin, heparin, clopidogrel, and glycoprotein IIb/IIIa inhibitors was also at the investigator’s discretion, and were administrated according to standard hospital procedure. |
IMPACT [35] | Aspirin 300 mg and clopidogrel 600 mg preloading in the ambulance and anticoagulated with a heparin bolus (70–100 U/kg) after arterial sheath insertion to achieve an activated clotting time (ACT) >250 s. Adjunctive pharmacotherapy, including abciximab and bivalirudin, was given at the operator’s discretion. |
Patients undergoing primary PCI received bivalirudin anticoagulation. | |
ITTI [38] | Aspirin (300Â mg loading followed by 100Â mg daily) and clopidogrel (300Â mg loading followed by 75Â mg daily) and unfractionated heparin 100Â IU/kg. |
Kaltoft 2006 [39] | Aspirin 300Â mg orally or intravenously, clopidogrel 300Â mg orally, and unfractionated heparin 10 000Â IE intravenously. During the intervention, all patients were treated with abciximab. |
Liistro 2009 [40] | Aspirin (a loading dose of 500 mg), heparin (70 IU/kg), and clopidogrel (a loading dose of 600 mg). All patients also received the glycoprotein IIb/IIIa inhibitor abciximab with an intravenous procedural bolus of 0.25 mg/kg followed by a continuous intravenous infusion of 0.125 μg/kg/min for 12 hours and postprocedural infusion without heparin. |
REMEDIA [41] | Heparin (initial weight-adjusted IV bolus then further boluses administered with the aim of obtaining an activated clotting time of 250 to 300 s in patients treated with abciximab and > 300 s in the remaining subjects) and with double antiplatelet therapy with aspirin and clopidogrel (loading dose of 300 mg followed by 75 mg/day) for at least four weeks. Unless contraindicated, abciximab (0.25 mg/kg bolus plus infusion of 0.125 μg/kg/min for 12 h) was intravenously administered in all patients undergoing primary PCI, whereas in those with failed thrombolysis, abciximab use was left to the operator’s discretion. |
Shehata 2014 [25] | Aspirin (a loading dose of 500Â mg), heparin (70Â IU/kg), and clopidogrel (a loading dose of 600Â mg). All patients also received the glycoprotein IIb/IIIa inhibitor abciximab with an intravenous procedural bolus of 0.25Â mg/kg followed by a continuous intravenous infusion of 0.125Â g/kg/min for 12Â hours and postprocedural infusion without heparin. |
Sim 2013 [42] | Aspirin 300 mg, clopidogrel 600 mg, intravenous unfractionated heparin and nitroglycerin. Oral atenolol 50–100 mg was given to optimize heart rate ≤ 65 beats per minute prior to CT scan, unless contraindicated. |
Aspirin (a loading dose of 500Â mg), heparin (5000Â IU), and clopidogrel (a loading dose of 600Â mg). Patients also received the glycoprotein IIb/IIIa inhibitor abciximab, with the dose based on body weight, unless contra-indicated, and additional heparin, with the dose based on the activated clotting time. | |
Patients received the following procedure-related medication: bivalirudin, clopidogrel or ticlopidine, acetylsalicylic acid, ticagrelor, prasugrel, heparin, low-molecular-weight heparin, and glycoprotein IIb/IIIa blocker. The use of platelet inhibitors or anticoagulants was left to the discretion of the treating physician. | |
TOTAL [6] | Unfractionated heparin; bivalirudin; enoxaparin and; glycoprotein IIb/IIa inhibitor. |
Heparin in ambulance. | |
VAMPIRE [47] | Aspirin and intravenous heparin boluses were administered during the procedure to maintain an activated clotting time ≥ 300 s. |
Yin 2011 [48] | Aspirin 300Â mg and clopidogrel 300Â mg prior to angiography. |