Fig 5

Resveratrol retarded HG-induced proliferation of mCFs via inhibition of ROS/ERK pathway. a HG time dependently promoted proliferation of mCFs. b Resveratrol as well as NAC inhibited proliferation of HG-induced mCFs. c HG upregulated ERK activity in a time dependent manner. d Resveratrol and NAC suppressed the elevated ERK activity induced by HG. e HG-induced proliferation of mCFs was normalized by U0126. *p < 0.05 between two groups; **p < 0.01 between two groups; bar = 50 μm