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Table 2 GEP variability performance results

From: Performance of gene-expression profiling test score variability to predict future clinical events in heart transplant recipients

Variability Score

Scores ≤ Threshold %

PPV %

NPV %

Sensitivity %

Specificity %

(95 % CI)

(95 % CI)

(95 % CI)

(95 % CI)

0.1

0.0

17.0 (−−)

-

100.0 (90.3–100)

0.0 (0.0–6.5)

0.2

1.1

17.2 (11.6–23.8)

100.0 (−−)

100.0 (90.3–100)

1.8 (0.0–9.7)

0.3

3.3

17.8 (12.3–24.7)

100.0 (−−)

100.0 (90.3–100)

5.5 (1.1–15.1)

0.4

7.7

19.0 (13.1–26.9)

100.0 (−−)

100.0 (90.3–100)

12.7 (5.3–24.5)

0.5

16.5

22.0 (15.2–30.8)

100.0 (−−)

100.0 (90.3–100)

27.3 (16.1–41.0)

0.6

24.2

23.3 (15.7–33.0)

97.0 (91.4–100.0)

94.4 (81.3–99.3)

36.4 (23.8–50.4)

0.7

33.0

23.2 (15.4–33.7)

92.8 (85.4–97.8)

83.3 (67.2–93.6)

43.6 (30.3–57.7)

0.8

42.9

25.2 (16.3–37.1)

91.4 (84.2–96.5)

75.0 (57.8–87.9)

54.5 (40.6–68.0)

0.9

56.0

29.7 (18.5–46.0)

90.3 (83.9–95.2)

63.9 (46.2–79.2)

69.1 (55.2–80.9)

1.0

62.6

26.0 (14.8–41.8)

87.4 (80.1–92.9)

50.0 (32.9–67.1)

70.9 (57.1–82.4)

1.1

68.1

27.8 (15.3–46.5)

87.0 (80.4–92.4)

44.4 (27.9–61.9)

76.4 (63.0–86-8)

1.2

71.4

29.9 (16.3–51.0)

87.0 (80.3–92.2)

41.7 (25.5–59.2)

80.0 (67.0–89.6)

1.3

76.9

29.4 (14.6–53.4)

86.0 (79.3–91.3)

33.3 (18.6–51.0)

83.6 (71.2–92.2)

1.4

83.5

31.9 (13.5–63.2)

85.3 (78.7–90.6)

25.0 (12.1–42.2)

89.1 (77.8–95.9)

1.5

87.9

35.4 (13.5–75.8)

84.9 (78.5–90.1)

19.4 (8.2–36)

92.7 (82.4–98.0)

1.6

92.3

29.4 (5.9–100.0)

83.9 (77.1–89.4)

11.1 (3.1–26.1)

94.5 (84.9–98.9)

1.7

94.5

31.9 (0.0–100.0)

83.7 (77.1–89.1)

8.3 (1.8–22.5)

96.4 (87.5–99.6)

1.8

97.8

23.8 (−−)

83.2 (76.6–88.6)

2.8 (0.1–14.5)

98.2 (90.3–100.0)

1.9

98.9

100.0 (−−)

83.4 (77.0–88.7)

2.8 (0.1–14.5)

100.0 (93.5–100.0)

2.0

98.9

100.0 (−−)

83.4 (77.0–88.7)

2.8 (0.1–14.5)

100.0 (93.5–100.0)

2.1

100.0

--- (−−)

83.0 (76.6–88.4)

0.0 (0.0–9.7)

100.0 (93.5–100.0)

  1. CI confidence interval, GEP gene expression profiling, NPV negative predictive value, PPV positive predictive value