Table 2 Clinical Phenotypes and Genotypes of rs2383206 SNP at the 9p21 Locus
| Â | Genotypes | Â | ||
|---|---|---|---|---|
| Â | GG | GA | AA | P |
N-332 | 88 | 190 | 54 | Â |
A. Demographics | ||||
Age | 58.57 ± 7.89 | 59.42 ± 7.48 | 60.11 ± 7.75 | 0.482 |
Male/Female | 72/16 | 161/29 | 47/7 | 0.689 |
Height (m) | 1.73 ± 0.09 | 1.74 ± 0.08 | 1.73 ± 0.08 | 0.462 |
Body weight (kg) | 84.12 ± 15.88 | 85.43 ± 16.11 | 84.00 ± 13.68 | 0.737 |
BMI (Kg/m2) | 27.97 ± 4.34 | 28.08 ± 4.59 | 28.12 ± 4.50 | 0.976 |
Hip/Waist | 1.11 ± 0.09 | 1.10 ± 0.09 | 1.11 ± 0.09 | 0.649 |
Systolic BP (mmHg) | 125.34 ± 15.18 | 124.03 ± 15.65 | 124.70 ± 14.55 | 0.797 |
Diastolic BP (mmHg) | 77.64 ± 8.59 | 76.34 ± 8.64 | 76.30 ± 9.37 | 0.492 |
Previous MI (%) | 35(39.75) | 73(38.4) | 22(40.7) | 0.945 |
Diabetes Mellitus (%) | 5 (1.5) | 5 (1.5) | 1 (0.3) | 0.337 |
Current smoker (%) | 19 (21.6) | 40 (21.1) | 9 (16.7) | 0.746 |
B. Plasma Lipid levels | ||||
Total Cholesterol (mg/dl) | 222.05 ± 23.74 | 220.14 ± 23.98 | 216.19 ± 23.74 | 0.384 |
HDL-C (mg/dl) | 44.27 ± 12.85 | 43.69 ± 11.24 | 43.80 ± 8.72 | 0.716* |
LDL-C (mg/dl) | 144.78 ± 19.74 | 144.02 ± 20.08 | 144.78 ± 19.74 | 0.750 |
LDL-C/HDL-C | 3.53 ± 0.97 | 3.50 ± 0.92 | 3.39 ± 0.79 | 0.647 |
Triglyceride (mg/dl) | 165.20 ± 64.87 | 162.33 ± 55.60 | 151.23 ± 48.01 | 0.691* |
Apo A1 (mg/dl) | 136.03 ± 31.37 | 131.81 ± 27.20 | 130.56 ± 20.40 | 0.619* |
Apo B (mg/dl) | 137.19 ± 22.16 | 134.17 ± 20.36 | 130.31 ± 19.44 | 0.157 |
ApoB/ApoA1 | 1.05 ± 0.26 | 1.06 ± 0.26 | 1.02 ± 0.23 | 0.666 |
Apo C-III (mg/dl) | 37.95 ± 13.36 | 38.28 ± 12.25 | 33.67 ± 9.85 | 0.0465 |
Lipoprotein (a) (mg/dl) | 40.07 ± 37.38 | 33.34 ± 31.98 | 33.87 ± 27.08 | 0.253* |
C. Quantitative Indices of Severity of Atherosclerosis | ||||
N = 288 | 77 | 162 | 49 | Â |
Number of coronary lesions (mean) | 3.09 ± 1.43 | 2.93 ± 1.37 | 3.06 ± 1.30 | 0.639 |
≥ 1 coronary lesion (%) | 77 (87.5) | 161 (84.7) | 49 (90.7) | 0.495 |
Number of coronary occlusions(mean) | 0.34 ± 0.59 | 0.27 ± 0.54 | 0.30 ± 0.50 | 0.636 |
≥ 1 coronary occlusion (%) | 25 (28.4) | 43 (22.6) | 15 (27.8) | 0.513 |
Baseline MLD (mm) | 1.65 ± 0.39 | 1.69 ± 0.40 | 1.68 ± 0.40 | 0.819 |