From: JTT-130, a microsomal triglyceride transfer protein (MTP) inhibitor lowers plasma triglycerides and LDL cholesterol concentrations without increasing hepatic triglycerides in guinea pigs
Diets
HMG-CoA Reductase
ACAT
CYP7
(pmol/min.mg)
Control
1.8 ± 0.8
0.8 ± 0.4
1.7 ± 1.8
LDI
2.7 ± 0.8
2.2 ± 0.9
1.2 ± 0.5
HDI
2.5 ± 1.4
3.5 ± 2.4
0.6 ± 0.7
Atorvastatin
3.4 ± 2.9
4.4 ± 3.1
0.7 ± 0.4