Skip to main content

Table 4 Hepatic total cholesterol (TC), free cholesterol (FC) cholesteryl ester (CE) and TG of guinea pigs fed a control diet, low dose MTPi (LDI), high dose MTPi (HDI) or atorvastatin1.

From: JTT-130, a microsomal triglyceride transfer protein (MTP) inhibitor lowers plasma triglycerides and LDL cholesterol concentrations without increasing hepatic triglycerides in guinea pigs

Diets

TC

FC

CE

TG

  

(mg/g)

 

Control (n = 10)

1.20 ± 0.53

1.00 ± 0.44

0.20 ± 0.23

16.2 ± 2.8

LDI (n = 10)

1.47 ± 0.40

1.24 ± 0.35

0.23 ± 0.11

13.9 ± 9.4

HDI (n = 9)

1.42 ± 0.66

0.98 ± 0.39

0.44 ± 0.58

13.5 ± 7.8

Atorvastatin (n = 9)

1.71 ± 0.76

1.31 ± 0.56

0.40 ± 0.39

18.8 ± 10.8

  1. 1Data are presented as mean ± SD for n = the number of guinea pigs indicated in parenthesis.
Back to article page

BMC Cardiovascular Disorders

ISSN: 1471-2261

Contact us