Table 1 Vasodilator responses after organ culture
From: Organ culture: a new model for vascular endothelium dysfunction
n | pEC50 (-log M) | P | Rmax (%) | P | ||
|---|---|---|---|---|---|---|
ACh | Control | 10 | 7.5 ± 0.2 | } n.s. | 93 ± 1 | } n.s. |
Cultured | 10 | 7.1 ± 0.1 | 93 ± 3 | |||
ACh, NO-mediated | Control | 10 | 7.2 ± 0.2 | } n.s. | 84 ± 6 | } <0.0001 |
Cultured | 10 | 7.1 ± 0.2 | 36 ± 6 | |||
ACh, prostaglandin-mediated | Control | 10 | 6.1 ± 0.4 | } n.s. | 48 ± 7 | } <0.001 |
Cultured | 10 | 6.6 ± 0.4 | 16 ± 4 | |||
ACh, EDHF-mediated | Control | 10 | 7.1 ± 0.2 | } n.s. | 83 ± 3 | } n.s. |
Cultured | 10 | 6.1 ± 0.5 | 80 ± 3 | |||
Forskolin | Control | 7 | 7.1 ± 0.2 | } n.s. | 95 ± 1 | } n.s. |
Cultured | 7 | 7.3 ± 0.2 | 97 ± 2 | |||
SNP | Control | 9 | 8.8 ± 0.1 | } n.s. | 96 ± 1 | } n.s. |
Cultured | 9 | 8.9 ± 0.2 | 93 ± 4 |