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Table 5 Hazard ratio and 95% confidence intervals of atrial fibrillation by birth weight category, stratified by gender, ARIC study, 1996-2008

From: Birth weight and the risk of atrial fibrillation in whites and African Americans: the Atherosclerosis Risk In Communities (ARIC) study

 

Birth weight categories

 

Men (N = 4,403, AF events = 453)

Low

Medium

High

P for trend

AF events, N

19

374

60

 

Person-years

982

36,754

6,410

 

Incidence Rate* (95% CI)

19.4 (12.0-29.6)

10.2 (9.2-11.2)

9.4 (7.2-12.0)

 

Model 1

1.92 (1.21, 3.04)

1 (ref.)

0.92 (0.70, 1.20)

0.07

Model 2

1.91 (1.20, 3.03)

1 (ref.)

0.92 (0.70, 1.20)

0.07

Model 3

1.91 (1.20, 3.04)

1 (ref.)

0.80 (0.61, 1.06)

0.009

Women (N = 5,729, AF events = 429)

Low

Medium

High

 

AF events, N

30

361

38

 

Person-years

3,680

52,227

4,685

 

Incidence Rate* (95% CI)

8.2 (5.6-11.5)

6.9 (6.2-7.7)

8.1 (5.8-11.0)

 

Model 1

1.17 (0.80, 1.69)

1 (ref.)

1.16 (0.83, 1.62)

0.92

Model 2

1.13 (0.78, 1.64)

1 (ref.)

1.17 (0.83, 1.63)

0.80

Model 3

1.23 (0.84, 1.79)

1 (ref.)

0.97 (0.67, 1.36)

0.51

  1. *Incidence rate per 1000 person years.
  2. Model 1: Cox proportional hazards model adjusted for age and gender.
  3. Model 2: As model 1, additionally adjusted for study center, income, and education.
  4. Model 3: As model 2, additionally adjusted for diabetes, systolic blood pressure, hypertension medications, smoking, height, body mass index, prevalent. myocardial infarction and heart failure.