Table 1 Characteristics of the included studies
Reference | Jadad score | Surgery type | Number NAC/control | NAC protocol | Medical history | Previous medication |
|---|---|---|---|---|---|---|
Ozaydin 2008 [12] | 4 | CABG ± valve | 58 /57 | 50 mg/kg iv for 1 h before surgery, then 50 mg/kg/day 48 h after operation | DM, Hypertension, CAD | BRB, ACEI, Statins, Acetylsalicylic acid |
Kazemi 2013 [16] | 5 | CABG ± valve | 120 /120 | 1200 mg orally 2 times per day from 48 h before and up to 72 h after heart surgery | DM,CRF,CAD, CHF, CLD, Hypertension, Hyperlipidemia | BRB,Statins, ACEI/ARB, Digoxin, Diuretic |
Eren 2003 [19] | 3 | CABG | 10 /10 | 100 mg/kg iv for 1 h before and 40 mg/kg/day at 24 h after CPB | CLD | Not reported |
Orhan 2006 [20] | 3 | CABG | 10 /10 | 50 mg/kg iv at the start of induction of anesthesia for 30 minutes | DM, CAD, Hypertension, Hyperlipidemia | Not reported |
Ozaydin 2013 [21] | 5 | CABG ± valve | 104 /104 | 50 mg/kg iv 1 h before and at the same does for 48 h after surgery | CHF, CLD, DM, CAD Hypertension | BRB, ACEI/ARB, Statins |
Peker 2008 [22] | 4 | CABG | 19 /21 | 50 mg/kg iv 1 h before surgery and 50 mg/kg/day 48 h after the operation | Not reported | Not reported |
Wijeysundera 2007 [23] | 5 | CABG ± valve | 88 /87 | 100 mg/kg iv over 30 min after induction of anesthesia, then 20 mg/kg/h for 4 h after CPB | CHF, CLD, DM, CVD, PVD, Hypertension | BRB, CCB, ACEI/ARB, NSAIDs |
EI-Hamamsy 2007 [24] | 3 | CABG | 50 /50 | 600 mg orally the day before and the morning of the operation, 150 mg/kg iv before skin incision, then 12.5 mg/kg/h over 24 h | CHF, CAD | BRB, CCB, ACEI |
Haase 2007 [25] | 5 | CABG ± valve | 30 /30 | 150 mg/kg iv after anesthesia induction, then 50 mg/kg iv over 4 h, then 100 mg/kg iv over 20 h | DM, CLD, CAD, PVD, Stroke, Hypertension, Hyperlipidemia, Carotid disease | Not reported |
Kim 2011 [26] | 4 | CABG | 24 /24 | 100 mg/kg iv bolus after anesthetic induction, then 40 mg/kg/day iv for 24 h | DM, Hypertension | BRB, CCB, ACEI, Diuretics |