Major adverse cardiovascular events in adult congenital heart disease: a population-based follow-up study from Taiwan

Table 3 Hazard ratios for incident MACE adjusted for age and sex, according to early and late study periods, and ConHD status

	n/N	(%)	Person-year	Follow-up time: ≥1.5 years		Follow-up time: 1.5 to 4 years		Follow-up time: over 4 years
				Adjusted HR (95% CI)	Pvalue	Adjusted HR (95% CI)	Pvalue	Adjusted HR (95% CI)	Pvalue
ConHD	487/2919	16.7%	26184.1	4.02 (3.49, 4.62)	<.0001	5.50 (4.32, 7.01)	<.0001	3.37 (2.83, 4.02)	<.0001
1.Cyanotic	52/236	22.0%	2058.8	10.30 (7.61, 13.94)	<.0001	15.12 (9.62, 23.78)	<.0001	7.88 (5.19, 11.95)	<.0001
TOF	44/191	23.0%	1678.5	11.07 (7.99, 15.33)	<.0001	18.94 (11.82, 30.35)	<.0001	7.46 (4.68, 11.91)	<.0001
CT	4/21	19.0%	182.7	-		-		-
DORV	1/6	16.7%	52.5	-		-		-
Other Cyanotic	3/18	16.7%	145.0	-		-		-
2. Non-Cyanotic	435/2683	16.2%	24125.4	3.80 (3.30, 4.39)	<.0001	5.14 (4.01, 6.59)	<.0001	3.22 (2.69, 3.86)	<.0001
VSD	136/1040	13.1%	9750.6	3.54 (2.89, 4.34)	<.0001	3.91 (2.75, 5.56)	<.0001	3.38 (2.63, 4.33)	<.0001
ASD	211/1223	17.3%	10734.0	3.73 (3.13, 4.44)	<.0001	5.17 (3.88, 6.88)	<.0001	3.07 (2.45, 3.85)	<.0001
PDA	54/275	19.6%	2393.7	5.93 (4.41, 7.96)	<.0001	9.87 (6.53, 14.94)	<.0001	3.82 (2.45, 5.95)	<.0001
PS	4/34	11.8%	317.7	-		-		-
Other Non Cyanotic	30/112	26.8%	940.4	-		-		-

MACE, major adverse cardiovascular events; ConHD, congenital heart disease; Cyanotic, cyanotic congenital heart disease; TOF, Tetrtology of fallot; CT, common truncus; DORV, double outlet right ventricle; Non-cyanotic, non-cyanotic congenital heart disease; VSD, ventricular septal defect; ASD, ostium or secundum type atrial septal defect; PDA, patent ductus arteriosus; PS, congenital stenosis of pulmonary valve. n, number of subjects with MACE; N, total number of subjects; Adjusted HR (95% CI), hazard ratio for incident MACE (95% confidence interval) adjusted for age and sex. All hazard ratios were comapred to reference cohort (N = 6,398). When the number of incidenct MACE was small (n < 40) in ConHD subgroup, the hazard ratio would not be estiamted by two follow-up period (the first 1.5 to 4 years, and after the fourth years).

ISSN: 1471-2261