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Table 4 Subgroup analysis for the effect of statin therapy on myocardial infarction

From: Effect of statins on cardiovascular events in patients with mild to moderate chronic kidney disease: a systematic review and meta-analysis of randomized clinical trials

Subgroup

Value

Reference

Statin

Control

Relative risk (95% CI)

p value

Heterogeneity

p value for heterogeneity

   

Event/total

Event/total

    

Mean Age

> = 65

29,32-34

92/2913

145/2948

0.66 [0.51, 0.85]

0.001

0%

0.44

 

<65

24,25

10/480

16/477

0.63 [0.27, 1.47]

0.283

3%

0.31

Cardiovascular History

Yes

29,34

82/1130

119/1160

0.67 [0.14, 3.22]

0.012

0%

0.53

 

No

25,32

4/192

7/205

0.71 [0.54, 0.93]

0.613

25.1%

0.25

Baseline Creatinine

> = 1.5

25,29

19/333

30/339

0.64 [0.37, 1.12]

0.120

0%

0.34

 

<1.5

24,32,34

75/1422

111/1457

0.70 [0.53, 0.93]

0.013

0%

0.55

Baseline LDL Cholesterol

> = 3.0

24,25, 29,32,34

94/1755

141/1796

0.69 [0.53, 0.88]

0.003

0%

0.704

 

<3.0

33

8/1638

20/1629

0.40 [0.18, 0.90]

0.027

-

-

LDL Cholesterol Lowering

> = 30%

29,33

25/1924

49/1922

0.52 [0.33, 0.84]

0.007

0%

0.418

 

<30%

24,25,32

12/625

22/636

0.55 [0.27, 1.13]

0.104

0%

0.505

Follow-up time

> = 3

24,29,32, 34

92/1708

140/1750

0.68 [0.53, 0.87]

0.003

0%

0.70

 

<3

25,33

10/1685

21/1675

0.59 [0.15, 2.27]

0.443

36%

0.21

  1. Abbreviations: CI confidential interval, LDL low density lipoprotein.