| Metformin |  | |
---|---|---|---|
 | No (N = 7778) | Yes (N = 7167) | P value |
Age, years | 57.72 ± 13.37 | 57.70 ± 12.55 | 0.937 |
Male gender | 4095 (52.6) | 3808 (53.1) | 0.565 |
Hypertension | 1885 (24.2) | 1695 (23.7) | 0.413 |
CAD | 671 (8.6) | 535 (7.5) | 0.010 |
Hyperlipidemia | 905 (11.6) | 849 (11.8) | 0.708 |
Atrial fibrillation | 69 (0.9) | 35 (0.5) | 0.005 |
Cancer | 372 (3.8) | 308 (4.3) | 0.155 |
Fracture | 538 (6.9) | 364 (5.1) | <0.001 |
Major surgery | 405 (5.2) | 321 (4.5) | 0.04 |
Medications | Â | Â | Â |
 Aspirin | 696 (8.9) | 692 (9.7) | 0.144 |
 Clopidogrel | 12 (0.2) | 8 (0.1) | 0.625 |
 Warfarin | 31 (0.4) | 36 (0.5) | 0.409 |
 Statin | 263 (3.4) | 342 (4.8) | <0.001 |
 HRT | 45 (0.6) | 54 (0.8) | 0.203 |
Other anti-hyperglycemic agents | Â | Â | Â |
 SU | 7652 (98.4) | 6941 (96.8) | <0.001 |
 Meglitinide | 2117 (27.2) | 626 (8.7) | <0.001 |
 α-glucosidase Inhibitor | 2629 (33.8) | 938 (13.1) | <0.001 |
 TZD | 2663 (34.2) | 1188 (16.6) | <0.001 |
 Insulin | 5377 (69.1) | 2342 (32.7) | <0.001 |
 Kind of drug used | 2.63 ± 0.84 | 2.68 ± 0.85 | <0.001 |