Low sex hormone-binding globulin is associated with hypertension: a cross-sectional study in a Swedish population

Table 2 The association between total testosterone, SHBG, oestradiol, free testosterone, respectively, and blood pressure in men and women

	Men 1,255				Women 1,259
	Systolic blood pressure		Diastolic blood pressure		Systolic blood pressure		Diastolic blood pressure
	β	p	β	P	β	p	β	P
*Model 1 Adjusted for age*
Total testosterone	-0.136	<0.001	-0.121	<0.001	-0.011	0.470	-0.013	0.638
Sex hormone-binding globulin	-0.114	<0.001	-0.143	<0.001	-0.031	0.193	-0.055	0.041
Oestradiol	-0.014	0.560	0.022	0.408	-0.035	0.144	-0.057	0.036
Free testosterone	-0.051	0.119	-0.051	0.154	0.009	0.698	0.016	0.574
*Model 2 Adjusted for age and BMI*
Total testosterone	-0.114	<0.001	-0.098	0.001	-0.008	0.873	-0.018	0.576
Sex hormone-binding globulin	-0.083	0.005	-0.117	<0.001	0.020	0.685	-0.018	0.610
Oestradiol	-0.019	0.440	0.017	0.530	-0.036	0.121	-0.025	0.461
Free testosterone	-0.039	0.243	-0.035	0.328	-0.016	0.570	-0.001	0.988
*Model 3 Adjusted for age, BMI, TG, HDL and CRP*
Total testosterone	-0.111	<0.001	-0.089	0.002	-0.002	0.932	-0.014	0.468
Sex hormone-binding globulin	-0.078	0.009	-0.105	0.001	0.043	0.146	0.004	0.908
Oestradiol	-0.026	0.295	0.000	0.999	-0.008	0.768	-0.020	0.556
Free testosterone	-0.034	0.348	-0.033	0.363	-0.019	0.487	-0.006	0.855
*Model 4 Adjusted for age, HOMA-IR, Tg, HDL and CRP*
Total testosterone	-0.123	<0.001	-0.097	0.001	0.005	0.846	-0.008	0.814
Sex hormone-binding globulin	-0.093	0.001	-0.113	<0.001	0.041	0.166	0.013	0.718
Oestradiol	-0.028	0.277	0.000	0.994	-0.004	0.902	-0.017	0.611
Free testosterone	-0.035	0.307	-0.032	0.878	-0.014	0.620	-0.005	0.876

BMI: Body mass index, Tg: triglycerides, HOMA-IR: homeostatic model assessment insulin resistance, HDL: high density lipoprotein, CRP: c-reactive protein, β: regressions coefficient, p: p value. Linear regression analysis is used to investigate the association between hormonal levels and blood pressure. All subjects with known hypertension (271) were excluded from the analyses.

ISSN: 1471-2261