From: Aragon workers’ health study – design and cohort description
Study | Aragon Workers’ Health Study (AWHS) | High-risk Plaque Initiative Biomage Study (HRP)[19] | Cardiovascular Health Study (CHS)[40] | Multi-Ethnic Study of Atherosclerosis (MESA)[41] | |
---|---|---|---|---|---|
Sample size | 5,400 | 7,687 | 15,792 | 5,888 | 5,800 |
Study population | Workers at an automobile assembly plant | Enrollees of a health plan free of CVD with at least 1 CVD risk factor | Probability sampling of household in participating communities | Probability sampling of Medicare elderly lists in participating communities | Volunteers free of CVD |
Age range (y) | 18 – 64 | Men: 55 – 80 | 45 – 64 | ≥65 | 45 – 84 |
Women: 60 – 80 | |||||
Baseline period | 2009 – 2010 | 2008 – 2009 | 1987 – 1998 | 1989 – 1993 | 2000 – 2002 |
Imaging methods at baseline | US (2D + 3D) of carotid, abdominal aorta, femoral and iliac arteries | US (2D + 3D) of carotid arteries and abdominal aorta | US (2D) of carotid arteries | US (2D) of carotid arteries | US (2D) of carotid arteries and abodminal |
ABI | ABI | aorta | |||
CACS | CACS | Retinal photograph | CACS | ||
ABI | ABI | ABI | |||
CE-MRI | Cardiac MRI | ||||
CT-angiography [18] F-FDG PET/CT | |||||
Follow-up visits | Annual | No | Every 3 years | Annual through 1999 | Every 2 years |
2005 – 2006 | |||||
Imaging methods during follow-up | Imaging methods repeated every 3 years | No | Imaging methods repeated every 3 years CE-MRI | Imaging methods repeated after 3 years | Imaging methods in subsamples |
Retinal photograph | CE-MRI |